{"id":"W2124734095","doi":"10.1007/s11248-012-9671-6","title":"Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT)","year":2012,"lang":"en","type":"article","venue":"Transgenic Research","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Danish Agency for Science and Higher Education; Forsknings- og Innovationsstyrelsen; Lundbeckfonden; Sundhedsvidenskabelige Fakultet, Aarhus Universitet; H. Lundbeck A/S; University of Toronto; Aarhus Universitet","keywords":"Biology; Transgenesis; Transgene; Somatic cell nuclear transfer; Recombinase; Genetics; Molecular biology; Cre recombinase; Gene; Reporter gene; Expression cassette; Site-specific recombination; Gene expression; Genetically modified mouse; Recombinant DNA; Reproductive technology; Vector (molecular biology); Recombination","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007295345,0.0001698966,0.0001817536,0.00007993872,0.0001404354,0.00001796551,0.0001196989,0.0002062627,0.0000959481],"category_scores_gemma":[0.00001459871,0.0001434451,0.0000603394,0.0002304097,0.0001762022,0.00001550933,0.00001442372,0.0001786983,0.0000106145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001818584,"about_ca_system_score_gemma":0.00006026123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006001685,"about_ca_topic_score_gemma":0.0000449238,"domain_scores_codex":[0.9982955,0.0002452675,0.000272918,0.0003886883,0.0003525374,0.0004450534],"domain_scores_gemma":[0.9993047,0.00001517042,0.00003134319,0.0002923378,0.0001854816,0.0001710422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003028322,0.0002591866,0.0005182184,0.000167047,0.00004384572,4.913758e-7,0.000929972,0.000005710896,0.9953794,0.000007678752,0.001245139,0.001140413],"study_design_scores_gemma":[0.00124626,0.001489063,0.00312002,0.0000150133,0.00004038139,0.00001040822,0.0002540967,0.0001838103,0.983403,0.000004403395,0.0100228,0.0002107753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993721,0.004101066,0.001120042,0.0002675445,0.00006189492,0.0005064355,0.0000471864,0.0000112127,0.0001636384],"genre_scores_gemma":[0.9959855,0.002659995,0.000286473,0.00002925632,0.0001710584,0.00003586904,0.0003444928,0.00004911281,0.0004382055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01197649,"threshold_uncertainty_score":0.5849523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06840207515766598,"score_gpt":0.2994665238165954,"score_spread":0.2310644486589294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}