{"id":"W2124768646","doi":"10.4049/jimmunol.179.8.5264","title":"Dynamic Changes in Accessibility, Nuclear Positioning, Recombination, and Transcription at the <i>Ig</i> κ Locus","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institutes of Health; University of Toronto","keywords":"Biology; Locus (genetics); Chromatin; Histone; Genetics; Gene; Molecular biology; Transcription (linguistics); Histone H3; Recombination; Enhancer; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009736487,0.00006852962,0.0000907524,0.00004169012,0.0001121228,0.00001273745,0.0002114278,0.00008900972,0.00001351923],"category_scores_gemma":[0.00003055476,0.00004283827,0.0000313247,0.00005256242,0.0001463322,0.000004406876,0.00007768749,0.0001438789,0.00000120386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004508549,"about_ca_system_score_gemma":0.00001651849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001522695,"about_ca_topic_score_gemma":0.0009170789,"domain_scores_codex":[0.9994187,0.0001026863,0.0002261505,0.00007171088,0.00005341435,0.0001272848],"domain_scores_gemma":[0.9995233,0.00002748887,0.0001952235,0.000153082,0.00008597832,0.00001490708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002421371,0.00003458639,0.0004953387,0.000004446123,0.00003921561,0.000002024668,0.0004352093,0.00003482785,0.994204,0.00008374848,0.00008349228,0.004340941],"study_design_scores_gemma":[0.007853218,0.005345965,0.6706176,0.0001579818,0.0002904792,0.00639291,0.008195097,0.001371622,0.266859,0.01183671,0.0202845,0.0007948636],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936305,0.002917951,0.0002778586,0.002775246,0.0001640829,0.00006928548,0.000001903232,0.000001440339,0.0001617168],"genre_scores_gemma":[0.9969391,0.002510036,0.00007940394,0.0003234518,0.00002472384,4.887338e-7,0.00000587492,0.000008844165,0.0001080387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.727345,"threshold_uncertainty_score":0.1746894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00452618878144003,"score_gpt":0.2272863286693756,"score_spread":0.2227601398879356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}