{"id":"W2124779091","doi":"10.1186/1742-4933-2-6","title":"The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging","year":2005,"lang":"en","type":"article","venue":"Immunity & Ageing","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health and Social Services Centre University Institute of Geriatrics of Sherbrooke; Université de Sherbrooke","funders":"","keywords":"Apoptosis; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Stimulation; Inflammation; Immunology; Medicine; Granulocyte; Programmed cell death; Signal transduction; Granulocyte macrophage colony-stimulating factor; Cell biology; Cytokine; Endocrinology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001876893,0.0002517502,0.0001996558,0.0002156813,0.00009437482,0.0001512255,0.0001221292,0.0001793762,0.000877914],"category_scores_gemma":[0.000227083,0.00006125924,0.0001534807,0.0001288407,0.0001565781,0.0001728047,0.0001698909,0.0001962118,0.000158168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001432203,"about_ca_system_score_gemma":0.0001188128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001863777,"about_ca_topic_score_gemma":0.0001429676,"domain_scores_codex":[0.9999229,0.00001761871,0.00001006646,0.00001494557,0.00001694814,0.00001756095],"domain_scores_gemma":[0.9998814,0.0000131295,0.00005313029,0.000009328467,0.00002180839,0.00002111022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004213721,0.0001696671,0.02870345,0.0002575315,0.00003092617,0.001134136,0.0003019457,0.0001123989,0.9527078,0.0001353121,0.0001173437,0.01211586],"study_design_scores_gemma":[0.00007227742,0.003709957,0.6142009,0.00005619296,0.0001345716,0.004748591,0.0002909955,0.0008574786,0.3719665,0.0003785656,0.003567736,0.0000161543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963322,0.002785911,0.0004272704,0.00002850937,0.000009073016,0.00001656534,0.0001293949,0.000006841355,0.0002643223],"genre_scores_gemma":[0.9980053,0.00100449,0.0004369517,0.00002115038,0.00001101166,0.00003075789,0.0001628844,0.000001357942,0.0003259709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000877914,"threshold_uncertainty_score":0.0029369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008269372274432859,"score_gpt":0.2162300538668368,"score_spread":0.2079606815924039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}