{"id":"W2124803334","doi":"10.1128/iai.01003-12","title":"Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP","year":2012,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Inflammasome; AMPK; Biology; Cell biology; Innate immune system; Pattern recognition receptor; Protein kinase A; Proinflammatory cytokine; Cytosol; AIM2; Receptor; Adenosine triphosphate; Caspase 1; Phosphorylation; Biochemistry; Inflammation; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001635079,0.0004651388,0.0004159063,0.0001729321,0.000125291,0.0003295672,0.0001647112,0.0003202586,0.001443634],"category_scores_gemma":[0.0001293742,0.0001338874,0.0001928234,0.0001987754,0.000259905,0.0002866933,0.0002128433,0.0006066704,0.0003940383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001816166,"about_ca_system_score_gemma":0.0001280193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001110076,"about_ca_topic_score_gemma":0.0001201494,"domain_scores_codex":[0.999782,0.00004021947,0.00002936672,0.00006144047,0.00005591456,0.00003105562],"domain_scores_gemma":[0.9999155,0.00001563118,0.00003647257,0.000009993618,0.000007872266,0.0000145705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000132956,0.0000155247,0.0000490629,0.00008001165,0.000003501981,0.00003426613,0.000006217242,0.00003631017,0.9988886,0.00006370099,0.00002997271,0.0006599262],"study_design_scores_gemma":[0.00002791959,0.0001823258,0.001667796,0.00000827128,0.000007238604,0.0001854314,0.000009664077,0.0005540968,0.9945346,0.00007387243,0.002745433,0.000003435818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695929,0.01026309,0.01537376,0.0003589413,0.0001953248,0.00009455383,0.000839723,0.0002427564,0.003038984],"genre_scores_gemma":[0.9876899,0.00333971,0.005865115,0.0001184789,0.00003618027,0.0001519188,0.0007284274,0.00002988978,0.002040487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001443634,"threshold_uncertainty_score":0.004829407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006913035160356717,"score_gpt":0.2272643615449251,"score_spread":0.2203513263845684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}