{"id":"W2124827891","doi":"10.1098/rsif.2010.0343.focus","title":"Safety paradigm: genetic evaluation of therapeutic grade human embryonic stem cells","year":2010,"lang":"en","type":"review","venue":"Journal of The Royal Society Interface","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"Wellcome Trust","keywords":"Embryonic stem cell; Stem cell; Genome editing; Regenerative medicine; Loss of heterozygosity; Biology; Computational biology; Biotechnology; Genome; Bioinformatics; Risk analysis (engineering); Genetics; Business; Gene; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006284283,0.001019022,0.00118439,0.001574716,0.0003141339,0.001520785,0.001896348,0.002567361,0.001807489],"category_scores_gemma":[0.003828612,0.0002432846,0.0007077843,0.000848373,0.002616453,0.001840477,0.001041701,0.002656046,0.001595268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001654485,"about_ca_system_score_gemma":0.001666171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007273015,"about_ca_topic_score_gemma":0.0005573831,"domain_scores_codex":[0.997658,0.0005927107,0.0002143117,0.0002123459,0.001253826,0.00006875969],"domain_scores_gemma":[0.9977996,0.001091321,0.0002205528,0.0001711687,0.0006419428,0.00007545387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001348262,0.0001243054,0.0004136737,0.00570935,0.00006614835,0.0009075911,0.0001833355,0.001241312,0.03370649,0.06686066,0.02325715,0.8673952],"study_design_scores_gemma":[0.00004333846,0.0004310535,0.0008327057,0.001800756,0.00007635244,0.00334268,0.0001442255,0.0006180134,0.03929554,0.02613014,0.9272419,0.00004340303],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003025344,0.9022591,0.05131269,0.009977325,0.002935666,0.0001965572,0.0001674468,0.0001508097,0.02997506],"genre_scores_gemma":[0.03946071,0.897844,0.03420257,0.006264963,0.001755461,0.000346889,0.0002953038,0.00006801963,0.01976215],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006284283,"threshold_uncertainty_score":0.03323483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.052650080000421,"score_gpt":0.3594870103115022,"score_spread":0.3068369303110812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}