{"id":"W2124879766","doi":"10.1101/gad.1765109","title":"MyoD and E-protein heterodimers switch rhabdomyosarcoma cells from an arrested myoblast phase to a differentiated state","year":2009,"lang":"en","type":"article","venue":"Genes & Development","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stem Cell Network; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; National Cancer Institute; Fred Hutchinson Cancer Research Center; Amgen","keywords":"MyoD; PITX2; Biology; Myogenin; MyoD Protein; Myogenesis; Myocyte; Cell biology; MYF5; Molecular biology; Cellular differentiation; Rhabdomyosarcoma; Cancer research; Gene expression; Genetics; Gene; Sarcoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001721609,0.0003234757,0.0002048779,0.0001523675,0.0001511102,0.0003395108,0.0002367546,0.0001950886,0.001385748],"category_scores_gemma":[0.0001167735,0.0002353767,0.00020189,0.0001015447,0.000310319,0.0001577407,0.0003086513,0.0005131723,0.0006048915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002989934,"about_ca_system_score_gemma":0.0001672995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000321208,"about_ca_topic_score_gemma":0.0007569343,"domain_scores_codex":[0.9998054,0.0000278448,0.00002230393,0.00004770261,0.00004542201,0.00005136543],"domain_scores_gemma":[0.9998953,0.00001521882,0.00002435965,0.00001580697,0.00000667212,0.00004259608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003399025,0.00001587673,0.0001967071,0.000007326607,0.000002725889,0.00002504114,0.000004573327,0.00001446622,0.9992674,0.0001284882,0.00001479541,0.0002886656],"study_design_scores_gemma":[0.00001457272,0.00008928542,0.003552223,0.000003069887,0.000007488483,0.0002151991,0.0000294028,0.0004322647,0.9935596,0.00003853097,0.002056097,0.00000227312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995546,0.0007295084,0.001829216,0.00004269858,0.00001878513,0.00001535445,0.0001100349,0.00004556168,0.001662874],"genre_scores_gemma":[0.9947754,0.0003108325,0.001748777,0.00004361209,0.000004109791,0.00002068971,0.0002526732,0.00002318866,0.002820602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001385748,"threshold_uncertainty_score":0.004635811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137795994114061,"score_gpt":0.2556801797938021,"score_spread":0.2443022198526615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}