{"id":"W2124890939","doi":"10.1158/1078-0432.ccr-11-1431","title":"Integrative Genomics Identified <i>RFC3</i> As an Amplified Candidate Oncogene in Esophageal Adenocarcinoma","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre","funders":"Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust; University of Michigan","keywords":"Biology; Carcinogenesis; Cancer; Gene duplication; Oncogene; Copy-number variation; Gene knockdown; Candidate gene; Malignancy; Cancer research; CDKN2A; Barrett's esophagus; Comparative genomic hybridization; Genomics; Adenocarcinoma; Gene; Genome; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.005762968,0.0003439634,0.0008684995,0.000478014,0.0002469311,0.0001075502,0.0005230397,0.0003320612,0.001541934],"category_scores_gemma":[0.001047441,0.0002712697,0.0002610173,0.001011122,0.0007700945,0.0004167016,0.0003552501,0.002355847,0.0008066266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001759735,"about_ca_system_score_gemma":0.002455706,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009375657,"about_ca_topic_score_gemma":0.003987378,"domain_scores_codex":[0.9933593,0.001295646,0.0009940099,0.0009451716,0.001467786,0.001938093],"domain_scores_gemma":[0.9953065,0.0008796289,0.0001180597,0.001006257,0.0005712751,0.0021183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007329459,0.002421675,0.950022,0.0001335135,0.0002939386,0.001160475,0.001628287,0.000003236204,0.0008750817,0.001343112,0.004055302,0.03073393],"study_design_scores_gemma":[0.009979754,0.004337641,0.9595425,0.0002474306,0.0001067148,0.00008092543,0.001264448,0.00009897805,0.01581667,0.001690229,0.006414687,0.000420036],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705478,0.0217481,0.00001616657,0.001600233,0.0004860268,0.001726017,0.00009117188,0.00005862424,0.003725877],"genre_scores_gemma":[0.988212,0.00356564,0.0002329869,0.0008047618,0.001744617,0.0007230311,0.0001377709,0.00008193307,0.004497181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0303139,"threshold_uncertainty_score":0.999974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.209089250673476,"score_gpt":0.5412453445037941,"score_spread":0.3321560938303181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}