{"id":"W2124936150","doi":"10.1161/01.res.0000251744.06138.50","title":"Transcriptional Silencing of the Death Gene BNIP3 by Cooperative Action of NF-κB and Histone Deacetylase 1 in Ventricular Myocytes","year":2006,"lang":"en","type":"article","venue":"Circulation Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Transactivation; Trichostatin A; HDAC1; Transcription factor; Histone deacetylase; Biology; Cell biology; Psychological repression; Gene silencing; NF-κB; Transcription (linguistics); Chromatin immunoprecipitation; Regulation of gene expression; Promoter; Myocyte; Gene expression; Histone; Gene; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001882126,0.0003492188,0.0002633327,0.0001042292,0.00012412,0.0002207113,0.0002014309,0.0001285182,0.0005275262],"category_scores_gemma":[0.0001007571,0.0001681495,0.0002896271,0.00009901535,0.0002807795,0.0001455901,0.0003000331,0.0004492249,0.0002057638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002717947,"about_ca_system_score_gemma":0.0002082457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004301571,"about_ca_topic_score_gemma":0.0006391741,"domain_scores_codex":[0.9998735,0.00001580313,0.00001447407,0.00003231164,0.00002817235,0.0000358481],"domain_scores_gemma":[0.9999011,0.00001537074,0.0000368898,0.00001440638,0.000009578523,0.00002283248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000386434,0.00000338653,0.00009211378,0.00001157823,0.000002673399,0.00002679749,0.000006346293,0.00001452135,0.9994606,0.00002544492,0.000006278838,0.0003117144],"study_design_scores_gemma":[0.00002575982,0.000246539,0.008985535,0.00000725273,0.00002376551,0.0003647723,0.00004579104,0.0008823471,0.9881561,0.0001033463,0.001154472,0.000004315746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905486,0.002153348,0.006027084,0.00008420242,0.0000283608,0.00001705018,0.0002174288,0.00005880217,0.0008651515],"genre_scores_gemma":[0.9954045,0.0008032839,0.002197778,0.00005341599,0.00001588089,0.00002992556,0.0003331455,0.00001809375,0.001144049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005275262,"threshold_uncertainty_score":0.00197202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03967609310266987,"score_gpt":0.3486998096478691,"score_spread":0.3090237165451992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}