{"id":"W2124936150","doi":"10.1161/01.res.0000251744.06138.50","title":"Transcriptional Silencing of the Death Gene BNIP3 by Cooperative Action of NF-κB and Histone Deacetylase 1 in Ventricular Myocytes","year":2006,"lang":"en","type":"article","venue":"Circulation Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Transactivation; Trichostatin A; HDAC1; Transcription factor; Histone deacetylase; Biology; Cell biology; Psychological repression; Gene silencing; NF-κB; Transcription (linguistics); Chromatin immunoprecipitation; Regulation of gene expression; Promoter; Myocyte; Gene expression; Histone; Gene; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007659623,0.00009250821,0.0001369641,0.000166547,0.0001299199,0.00001268505,0.0001343298,0.0001342569,0.0000226371],"category_scores_gemma":[0.0002017732,0.00008240798,0.00005993219,0.0003864458,0.0002828777,0.00001189235,0.00005914614,0.0002107405,0.000001553606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001355527,"about_ca_system_score_gemma":0.0002018615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002298,"about_ca_topic_score_gemma":0.0001856739,"domain_scores_codex":[0.9982381,0.0003746242,0.0003024979,0.0002815498,0.0005698142,0.0002334186],"domain_scores_gemma":[0.9991825,0.00005603149,0.00007061047,0.0002314877,0.0004148682,0.00004456608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006039514,0.0001192417,0.01086668,0.00004323174,0.00001177393,0.000002158063,0.00006978599,0.002955527,0.9849781,0.0002043846,0.0004767291,0.0002120352],"study_design_scores_gemma":[0.0005985358,0.00007044155,0.05307912,0.00002894694,0.000004245158,0.000009979996,0.00008197068,0.001201945,0.9444321,0.00006051139,0.0003584032,0.00007378424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960811,0.002601462,0.0005318763,0.0001195107,0.00003254843,0.0003691383,0.00004005015,0.000002872301,0.0002214651],"genre_scores_gemma":[0.9993364,0.00008031219,0.00006224893,0.00000640411,0.00005953406,0.00003308991,0.0001189306,0.0000135588,0.000289537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04221244,"threshold_uncertainty_score":0.33605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03967609310266987,"score_gpt":0.3486998096478691,"score_spread":0.3090237165451992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}