{"id":"W2124950819","doi":"10.1128/jvi.01440-13","title":"Herpes Simplex Virus 1-Encoded Tegument Protein VP16 Abrogates the Production of Beta Interferon (IFN) by Inhibiting NF-κB Activation and Blocking IFN Regulatory Factor 3 To Recruit Its Coactivator CBP","year":2013,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Terry Fox Research Institute","funders":"","keywords":"Biology; Coactivator; Transactivation; Interferon; Herpes simplex virus; Interferon regulatory factors; Innate immune system; Sendai virus; Cell biology; Transcription factor; Molecular biology; Virology; Virus; Immune system; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003346617,0.0001808251,0.0003928946,0.0001908933,0.0001316395,0.00002608631,0.00007163212,0.0001362705,0.0001727847],"category_scores_gemma":[0.000276625,0.0001174945,0.00007825164,0.0001516691,0.00008377266,0.0003127304,0.00005100275,0.0002892972,0.00001249747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001898639,"about_ca_system_score_gemma":0.00007192249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000153433,"about_ca_topic_score_gemma":0.00002213804,"domain_scores_codex":[0.998562,0.0001655858,0.0006036417,0.0002064331,0.0002391732,0.0002231333],"domain_scores_gemma":[0.9986912,0.0001159179,0.0006199799,0.0001616574,0.000285615,0.0001256524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003589547,0.0003225,0.001148721,0.00004461759,0.0002679809,0.000002734648,0.000645699,0.00001355051,0.9123952,0.0000170922,0.0007444923,0.08403849],"study_design_scores_gemma":[0.0009082523,0.001644817,0.01151436,0.0003010323,0.00009245209,0.00009672689,0.0003195514,0.00003488315,0.9779883,0.00009957671,0.006904351,0.00009571997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945198,0.0001531197,0.0001384812,0.003951494,0.0001649888,0.000983238,0.00000549677,0.00001340834,0.00006995093],"genre_scores_gemma":[0.9988774,0.00003291355,0.0003041242,0.0001949423,0.0002133431,0.0000460269,0.000002391259,0.00002283781,0.0003060344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08394277,"threshold_uncertainty_score":0.4791286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223688955492229,"score_gpt":0.2809357009754127,"score_spread":0.2586988114204904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}