{"id":"W2124950819","doi":"10.1128/jvi.01440-13","title":"Herpes Simplex Virus 1-Encoded Tegument Protein VP16 Abrogates the Production of Beta Interferon (IFN) by Inhibiting NF-κB Activation and Blocking IFN Regulatory Factor 3 To Recruit Its Coactivator CBP","year":2013,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Terry Fox Research Institute","funders":"","keywords":"Biology; Coactivator; Transactivation; Interferon; Herpes simplex virus; Interferon regulatory factors; Innate immune system; Sendai virus; Cell biology; Transcription factor; Molecular biology; Virology; Virus; Immune system; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266155,0.0005092286,0.0002669776,0.000188365,0.00008497943,0.0002172809,0.0002628939,0.0002057732,0.0009103284],"category_scores_gemma":[0.0000861024,0.0001499949,0.0003583452,0.0001126807,0.0002946578,0.000211116,0.000130223,0.0006939582,0.0003079324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002322181,"about_ca_system_score_gemma":0.0002132725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003101619,"about_ca_topic_score_gemma":0.0002832372,"domain_scores_codex":[0.9998815,0.00002085386,0.00001505724,0.0000203424,0.00002643839,0.00003581025],"domain_scores_gemma":[0.9999145,0.00001814548,0.00002735992,0.00001346635,0.000006786978,0.00001963975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001521225,0.0000561509,0.0001024654,0.00004010272,0.000009590889,0.0000306553,0.000007944866,0.00006222538,0.9984793,0.000107225,0.00002081909,0.0009312482],"study_design_scores_gemma":[0.00001993378,0.0004314616,0.001480481,0.000004425592,0.00001296333,0.0002375407,0.000007947938,0.0004121319,0.9958502,0.00003977203,0.001500885,0.00000226318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943651,0.002647234,0.001749888,0.0000507083,0.00004703475,0.0000227004,0.0001604241,0.00005930889,0.0008975837],"genre_scores_gemma":[0.9940322,0.001613111,0.001709579,0.00002707379,0.0000145142,0.00003494056,0.0005096212,0.00002318062,0.002035789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009103284,"threshold_uncertainty_score":0.00304538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223688955492229,"score_gpt":0.2809357009754127,"score_spread":0.2586988114204904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}