{"id":"W2124969332","doi":"10.1073/pnas.0703285104","title":"Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; McGill University","keywords":"Innate immune system; Biology; RIG-I; RNA silencing; Interferon; DNA virus; DNA; Cell biology; RNA; Signal transduction; MDA5; Nucleic acid; Virology; NS3; RNA interference; Virus; Gene; Immune system; Hepatitis C virus; Genome; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002441662,0.0002830739,0.0002977247,0.0002988455,0.0001474578,0.0006429193,0.000119827,0.000289938,0.002552893],"category_scores_gemma":[0.0003685831,0.0001676238,0.0002889925,0.0001943493,0.000240072,0.0002227455,0.000316733,0.0003373382,0.001042661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004184066,"about_ca_system_score_gemma":0.0004040081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00021062,"about_ca_topic_score_gemma":0.0002066324,"domain_scores_codex":[0.9996516,0.00008384274,0.00002402831,0.00008387466,0.0001060499,0.00005060086],"domain_scores_gemma":[0.9997764,0.00004785688,0.00005825995,0.00004615366,0.00002666496,0.00004456648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00034056,0.00004680255,0.001616833,0.00006978849,0.00002646362,0.0002541059,0.00005081983,0.00007277967,0.9892854,0.0007032076,0.0001169847,0.00741629],"study_design_scores_gemma":[0.0001356331,0.001009756,0.02370845,0.00005293825,0.00007282363,0.003916455,0.0002355906,0.0009650697,0.9485484,0.001008924,0.0203349,0.00001114061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969373,0.01085921,0.009225396,0.0004118728,0.00007082822,0.0001080116,0.0006350943,0.0002175125,0.009099101],"genre_scores_gemma":[0.9875218,0.003028037,0.004918412,0.0001562932,0.00003615621,0.00006192961,0.000966445,0.00001285685,0.003297998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002552893,"threshold_uncertainty_score":0.008540273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04718122755722968,"score_gpt":0.3120165838513472,"score_spread":0.2648353562941175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}