{"id":"W2124969332","doi":"10.1073/pnas.0703285104","title":"Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; McGill University","keywords":"Innate immune system; Biology; RIG-I; RNA silencing; Interferon; DNA virus; DNA; Cell biology; RNA; Signal transduction; MDA5; Nucleic acid; Virology; NS3; RNA interference; Virus; Gene; Immune system; Hepatitis C virus; Genome; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002286236,0.0001274055,0.0002434766,0.0002954001,0.0002450432,0.00002118382,0.0005111375,0.0002041512,0.00002247348],"category_scores_gemma":[0.00003633905,0.00008973981,0.00006663664,0.0004045318,0.001104228,0.0002960046,0.0001022812,0.0003598479,0.000001909873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002537428,"about_ca_system_score_gemma":0.00002936738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003896816,"about_ca_topic_score_gemma":0.00000178857,"domain_scores_codex":[0.9988281,0.0000166629,0.000469519,0.0002316149,0.0001932247,0.0002608499],"domain_scores_gemma":[0.9994127,0.0001453886,0.0003137767,0.000009851303,0.0001050214,0.0000133154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007156464,0.0000695382,0.001510456,0.00002983935,0.0000190254,3.011297e-8,0.0006725028,0.000002417256,0.9865255,0.01007011,0.00003606926,0.0003488763],"study_design_scores_gemma":[0.002117353,0.0001214079,0.01197071,0.000130881,0.000006615895,0.00001194673,0.0005098001,0.000002958604,0.982169,0.002722983,0.0001353871,0.0001009058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926613,0.000211491,5.333182e-7,0.0003553665,0.0000468662,0.0002114788,0.000007004416,0.0000110284,0.006494942],"genre_scores_gemma":[0.9994997,0.00001151113,0.00003964397,0.00008703875,0.00001831681,0.000003385623,4.522142e-7,0.000004223601,0.0003357441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01046025,"threshold_uncertainty_score":0.4068573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04718122755722968,"score_gpt":0.3120165838513472,"score_spread":0.2648353562941175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}