{"id":"W2124999217","doi":"10.1242/dev.111906","title":"BMP-mediated induction of GATA4/5/6 blocks somitic responsiveness to SHH","year":2014,"lang":"en","type":"article","venue":"Development","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Biology; GLI1; GATA4; Cell biology; Transcription factor; Mesoderm; Gene knockdown; Sonic hedgehog; Hedgehog signaling pathway; Paraxial mesoderm; Genetics; Signal transduction; Gene; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003410761,0.0001173544,0.000147751,0.00007355471,0.00006508889,0.000005836016,0.000120713,0.00008575499,0.00001040246],"category_scores_gemma":[0.0004538116,0.000113648,0.00002826423,0.0001137209,0.00003641885,0.000001301262,0.0001238469,0.00004352512,0.00003611036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002504173,"about_ca_system_score_gemma":0.0001500762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004769256,"about_ca_topic_score_gemma":0.00001567082,"domain_scores_codex":[0.9991275,0.00005872114,0.000234926,0.0002531155,0.0001392385,0.0001864945],"domain_scores_gemma":[0.9994853,0.00002550579,0.00005851211,0.0002037452,0.0001537643,0.00007318732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007927692,0.00004089192,0.001936213,0.00002334747,0.00006312354,0.000001446189,0.0005756345,0.00007746763,0.9884782,0.00001996036,0.001154323,0.007550045],"study_design_scores_gemma":[0.0002776019,0.0001162681,0.02485033,0.00003260887,0.000006048243,0.000003230937,0.0001047797,0.000005752548,0.8632349,0.00001200438,0.1112019,0.0001545283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959198,0.00007783221,0.003079866,0.0001474152,0.0002008452,0.0001433926,0.000004789983,0.00001311851,0.0004129771],"genre_scores_gemma":[0.9959146,0.000008254786,0.003180391,0.0002608041,0.00009115256,0.00004019693,0.00006326727,0.00001440926,0.0004269094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1252433,"threshold_uncertainty_score":0.4634433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01537772068298721,"score_gpt":0.2459577552656814,"score_spread":0.2305800345826942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}