{"id":"W2125024218","doi":"10.1128/aac.02163-12","title":"Rifaximin Resistance in Escherichia coli Associated with Inflammatory Bowel Disease Correlates with Prior Rifaximin Use, Mutations in <i>rpoB</i> , and Activity of Phe-Arg-β-Naphthylamide-Inhibitable Efflux Pumps","year":2012,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Rifaximin; Inflammatory bowel disease; Efflux; Microbiology; rpoB; Ulcerative colitis; Internal medicine; Escherichia coli; Gastroenterology; Biology; Medicine; Antibiotics; Bacteria; Biochemistry; Disease; Genetics; Gene; 16S ribosomal RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003675184,0.0003156996,0.0002836261,0.0005672914,0.0003160823,0.0004496449,0.0001647981,0.0004757212,0.001214477],"category_scores_gemma":[0.002253959,0.0002879067,0.0001483593,0.0004777896,0.0004443969,0.0002699168,0.0002728951,0.0005040694,0.0003736834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001465028,"about_ca_system_score_gemma":0.0001112697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006809926,"about_ca_topic_score_gemma":0.0007466794,"domain_scores_codex":[0.9995297,0.0001443057,0.00006406195,0.00009463229,0.00008039675,0.00008685826],"domain_scores_gemma":[0.9979295,0.0004716418,0.0009895029,0.0001030304,0.0001693292,0.0003370775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004654575,0.0001311654,0.9868493,0.00003233824,0.00002766237,0.0007463524,0.00009313125,0.00002472811,0.008317548,0.000009003681,0.00007903931,0.003224266],"study_design_scores_gemma":[0.00001087931,0.0003619275,0.9949687,0.000007916992,0.00002263871,0.003376653,0.0001024632,0.00008914274,0.0008720631,0.000008652498,0.0001749968,0.000003973885],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999301,0.0003840496,0.0000509657,0.00002386289,0.000003594535,0.000004616623,0.0000229557,0.000003613208,0.0002053485],"genre_scores_gemma":[0.9996402,0.0001226888,0.00008506738,0.00001671553,0.00001332947,0.00000273523,0.00005288385,0.000001022216,0.0000652516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001214477,"threshold_uncertainty_score":0.004062831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006876173756701014,"score_gpt":0.2152659409076282,"score_spread":0.2083897671509272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}