{"id":"W2125028785","doi":"10.1182/blood-2006-05-023796","title":"A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; St. Michael's Hospital","funders":"","keywords":"Receptor antagonist; Immunology; Receptor; Medicine; Mechanism of action; Interleukin; Immune system; Interleukin 1 receptor antagonist; Proinflammatory cytokine; Cytokine; Biology; Antagonist; Inflammation; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007823317,0.0005504298,0.0009501813,0.0003057355,0.0002053373,0.001125005,0.0003996098,0.001186604,0.003028218],"category_scores_gemma":[0.0004781922,0.0001568965,0.0003852193,0.0001539464,0.0008668883,0.0009207381,0.0002580871,0.001550818,0.0008187442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004193781,"about_ca_system_score_gemma":0.0003556342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001166456,"about_ca_topic_score_gemma":0.00009634952,"domain_scores_codex":[0.9996521,0.0001332514,0.00003218254,0.00004720617,0.00003869064,0.00009649032],"domain_scores_gemma":[0.9996371,0.000118958,0.0001042627,0.00004419479,0.0000318832,0.00006348942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006625108,0.001230733,0.003147435,0.002963562,0.0001089705,0.003753757,0.0003183207,0.0006095706,0.5180328,0.02574613,0.005119548,0.432344],"study_design_scores_gemma":[0.002640232,0.01967262,0.01335115,0.001810379,0.0008036129,0.01934258,0.0005667306,0.003961722,0.6377229,0.01602375,0.2840208,0.00008346055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.291221,0.5970912,0.05061117,0.02370932,0.003778258,0.0005625354,0.0003538684,0.001000186,0.03167243],"genre_scores_gemma":[0.8768848,0.08820999,0.01645764,0.005471288,0.004468032,0.0004552735,0.00014255,0.00007393742,0.007836441],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003028218,"threshold_uncertainty_score":0.01013041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00831932442796028,"score_gpt":0.2572748859433157,"score_spread":0.2489555615153554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}