{"id":"W2125042440","doi":"10.1016/j.bbadis.2009.10.005","title":"A suggested role for mitochondria in Noonan syndrome","year":2009,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Mitochondrion; Oxidative phosphorylation; Mitochondrial ROS; Oxidative stress; Reactive oxygen species; Biology; Cell biology; Inner mitochondrial membrane; Intermembrane space; Mitochondrial disease; Phosphorylation; Chemistry; Biochemistry; Mitochondrial DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003572546,0.0007644085,0.0005713709,0.001502004,0.0007125349,0.0008904478,0.001713323,0.002984446,0.002730385],"category_scores_gemma":[0.001349436,0.0002372676,0.0005191987,0.0005128596,0.001334893,0.001156635,0.0007108431,0.0009812915,0.0004701647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004327449,"about_ca_system_score_gemma":0.0004440069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005760569,"about_ca_topic_score_gemma":0.0003240717,"domain_scores_codex":[0.9998203,0.00003479956,0.00002801823,0.00004715372,0.00003416953,0.00003557591],"domain_scores_gemma":[0.99939,0.0002440806,0.00009435252,0.00007159652,0.00007431745,0.0001255876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.004377209,0.0002726588,0.04940744,0.001545931,0.0004207943,0.273325,0.001476041,0.001954079,0.5393106,0.0942217,0.003029681,0.03065888],"study_design_scores_gemma":[0.001214926,0.002502766,0.0619662,0.0004236447,0.001178722,0.4761161,0.001699659,0.01221515,0.2892269,0.06941952,0.08381691,0.0002194295],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8996369,0.04254484,0.02477471,0.009499946,0.002765086,0.0001348601,0.0006850001,0.0007757553,0.01918304],"genre_scores_gemma":[0.98953,0.004664669,0.003101742,0.0003082442,0.000403665,0.00003204235,0.0001400953,0.00001475518,0.001804845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002984446,"threshold_uncertainty_score":0.009134114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00544670044670487,"score_gpt":0.2478180394983612,"score_spread":0.2423713390516564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}