{"id":"W2125042440","doi":"10.1016/j.bbadis.2009.10.005","title":"A suggested role for mitochondria in Noonan syndrome","year":2009,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Mitochondrion; Oxidative phosphorylation; Mitochondrial ROS; Oxidative stress; Reactive oxygen species; Biology; Cell biology; Inner mitochondrial membrane; Intermembrane space; Mitochondrial disease; Phosphorylation; Chemistry; Biochemistry; Mitochondrial DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001336439,0.0004473469,0.0004513884,0.0001724015,0.00005800666,0.0000458285,0.0006343349,0.0001815584,0.000007819236],"category_scores_gemma":[0.0003017791,0.0004743946,0.0004630788,0.0003450389,0.0001407958,0.00002041606,0.0001569258,0.0001191509,0.000005970427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003381247,"about_ca_system_score_gemma":0.000283961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002535625,"about_ca_topic_score_gemma":0.000005720588,"domain_scores_codex":[0.9976578,0.0001263748,0.0005100698,0.0008554725,0.0003122744,0.0005380035],"domain_scores_gemma":[0.9981814,0.0000285333,0.0002615335,0.001050073,0.000138869,0.0003395814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001072375,0.0007836201,0.000026557,0.0000740352,0.00008812836,0.00002506854,0.00001892997,0.00001984498,0.9958051,0.0009644639,0.0006184519,0.0005033957],"study_design_scores_gemma":[0.001640865,0.0008950732,0.02110729,0.0001061928,0.0001264415,0.000004819321,0.00001504407,0.00006328007,0.9738505,0.001380843,0.0002894538,0.0005201462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928707,0.002754751,0.0003200359,0.001814583,0.00006720392,0.001175975,0.0009037149,0.00003630389,0.00005670827],"genre_scores_gemma":[0.9946294,0.00009746887,0.002482708,0.0009917705,0.0000672677,0.0001990505,0.0014335,0.0000668953,0.00003197886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02195458,"threshold_uncertainty_score":0.9997708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00544670044670487,"score_gpt":0.2478180394983612,"score_spread":0.2423713390516564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}