{"id":"W2125044300","doi":"10.1074/mcp.m600319-mcp200","title":"A Proteomics Screen Implicates HSP83 and a Small Kinetoplastid Calpain-related Protein in Drug Resistance in Leishmania donovani Clinical Field Isolates by Modulating Drug-induced Programmed Cell Death","year":2006,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Centre Hospitalier Universitaire de Québec; Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Université Laval","keywords":"Biology; Miltefosine; Leishmania donovani; Drug resistance; Leishmania; Amastigote; Paromomycin; Programmed cell death; Microbiology; Antifungal drug; Leishmaniasis; Apoptosis; Immunology; Visceral leishmaniasis; Parasite hosting; Genetics; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002164799,0.0007595515,0.00130137,0.0004347367,0.0001873891,0.0001840641,0.0004589451,0.0005275633,0.000007889116],"category_scores_gemma":[0.0007838956,0.0007564063,0.0002576875,0.0009103158,0.0002219009,0.0001615268,0.0004643192,0.001885922,0.0000118901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000379169,"about_ca_system_score_gemma":0.0002850755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004169779,"about_ca_topic_score_gemma":0.00314769,"domain_scores_codex":[0.9938645,0.0006488202,0.001931156,0.001569679,0.0005522904,0.00143354],"domain_scores_gemma":[0.99774,0.0002601641,0.0005077207,0.0008913357,0.0002647883,0.0003359837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007805989,0.0009682314,0.08956076,0.0005618382,0.00008613573,0.000659611,0.0002736269,0.00003006913,0.905726,0.0003991229,0.0001747072,0.0007792804],"study_design_scores_gemma":[0.007367761,0.0005176716,0.01199223,0.000829166,0.00007481833,0.00002109417,0.0001213463,0.005118447,0.97048,0.00211628,0.0004540965,0.000907122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820208,0.001728704,0.002075824,0.002654021,0.00003776057,0.01064708,0.00001548975,0.0001646568,0.000655669],"genre_scores_gemma":[0.9387593,0.00007679102,0.05825958,0.0001633122,0.00007593283,0.001412731,0.0001126671,0.0001730785,0.000966661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07756853,"threshold_uncertainty_score":0.9994887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492939936701883,"score_gpt":0.2654069920631278,"score_spread":0.250477592696109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}