{"id":"W2125044300","doi":"10.1074/mcp.m600319-mcp200","title":"A Proteomics Screen Implicates HSP83 and a Small Kinetoplastid Calpain-related Protein in Drug Resistance in Leishmania donovani Clinical Field Isolates by Modulating Drug-induced Programmed Cell Death","year":2006,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Centre Hospitalier Universitaire de Québec; Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Université Laval","keywords":"Biology; Miltefosine; Leishmania donovani; Drug resistance; Leishmania; Amastigote; Paromomycin; Programmed cell death; Microbiology; Antifungal drug; Leishmaniasis; Apoptosis; Immunology; Visceral leishmaniasis; Parasite hosting; Genetics; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008827059,0.0002129267,0.0002228526,0.0003233089,0.0001415225,0.0001653886,0.0001267883,0.0002593914,0.0006858387],"category_scores_gemma":[0.000184191,0.00008785617,0.0001850334,0.0002595779,0.0001376284,0.00008756101,0.0001198841,0.0002204386,0.0001849781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001106597,"about_ca_system_score_gemma":0.00008593351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004114019,"about_ca_topic_score_gemma":0.0005644748,"domain_scores_codex":[0.9998938,0.00001432324,0.00001142861,0.00003221642,0.00002675036,0.0000214802],"domain_scores_gemma":[0.9998994,0.00002033219,0.00003086376,0.000007100615,0.0000240656,0.00001827411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008354494,0.00002279998,0.002533188,0.00002669709,0.000009949409,0.0002483375,0.00002283844,0.00001577043,0.9959128,0.000008152768,0.00002333757,0.001092462],"study_design_scores_gemma":[0.00002961783,0.001224085,0.2445867,0.00001007181,0.0001320312,0.009425536,0.0003016492,0.0006729407,0.7414236,0.00005669477,0.002126259,0.00001078764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985673,0.0003946014,0.000473184,0.00003737798,0.000005107578,0.000017151,0.0002460957,0.00001112183,0.0002480613],"genre_scores_gemma":[0.9972911,0.0002728633,0.001170376,0.00004796696,0.000005075415,0.00001169387,0.0006690267,0.000004790134,0.00052706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006858387,"threshold_uncertainty_score":0.002294362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01492939936701883,"score_gpt":0.2654069920631278,"score_spread":0.250477592696109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}