{"id":"W2125048552","doi":"10.1084/jem.194.6.757","title":"The Stress Kinase Mitogen-Activated Protein Kinase Kinase (Mkk)7 Is a Negative Regulator of Antigen Receptor and Growth Factor Receptor–Induced Proliferation in Hematopoietic Cells","year":2001,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Cell biology; Interleukin 33; Mitogen-activated protein kinase kinase; MAP kinase kinase kinase; ASK1; Cancer research; MAPK/ERK pathway; Biology; Mitogen-activated protein kinase; Kinase; Protein kinase A; Chemistry; Cytokine; Immunology; Interleukin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037466,0.0006124919,0.0002558256,0.0003607118,0.0003030913,0.0002858227,0.0002092597,0.0002017251,0.0009724647],"category_scores_gemma":[0.00008357092,0.0001849101,0.00027697,0.0001881618,0.0002276316,0.0002100465,0.0003200669,0.0004325977,0.0007927645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003292007,"about_ca_system_score_gemma":0.0002594309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002718279,"about_ca_topic_score_gemma":0.0003441243,"domain_scores_codex":[0.9998511,0.0000144845,0.00001076251,0.00002675249,0.00006938855,0.00002753668],"domain_scores_gemma":[0.9998946,0.000005904755,0.00003813638,0.000007259573,0.00002585294,0.0000282445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009317107,0.00001634178,0.0005338545,0.000118043,0.000009694261,0.0001436275,0.00001429897,0.00007387489,0.9932863,0.00028984,0.0002679786,0.005152968],"study_design_scores_gemma":[0.00002875057,0.000286842,0.01421464,0.00002583028,0.00003802426,0.001336127,0.00005107973,0.001109443,0.9602033,0.0003108472,0.02238104,0.00001419926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9330391,0.03840595,0.01621173,0.0005058349,0.0003594906,0.0001285065,0.001559842,0.0008884633,0.008901015],"genre_scores_gemma":[0.9733779,0.01243098,0.004630735,0.0001347694,0.00007802431,0.00009294326,0.001847697,0.00005542068,0.007351562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009724647,"threshold_uncertainty_score":0.003253281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01590358727249661,"score_gpt":0.2622320888387877,"score_spread":0.2463285015662911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}