{"id":"W2125048552","doi":"10.1084/jem.194.6.757","title":"The Stress Kinase Mitogen-Activated Protein Kinase Kinase (Mkk)7 Is a Negative Regulator of Antigen Receptor and Growth Factor Receptor–Induced Proliferation in Hematopoietic Cells","year":2001,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Cell biology; Interleukin 33; Mitogen-activated protein kinase kinase; MAP kinase kinase kinase; ASK1; Cancer research; MAPK/ERK pathway; Biology; Mitogen-activated protein kinase; Kinase; Protein kinase A; Chemistry; Cytokine; Immunology; Interleukin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003953642,0.0002143504,0.0003080819,0.00006970497,0.0001225968,0.00001284697,0.0002351017,0.0001099523,0.00006716617],"category_scores_gemma":[0.000160207,0.0001199947,0.00006097234,0.000153971,0.0002393976,0.0000182945,0.0000707151,0.0001804394,0.000001339161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000440009,"about_ca_system_score_gemma":0.00007968554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008529973,"about_ca_topic_score_gemma":0.00001036673,"domain_scores_codex":[0.9984546,0.0002751977,0.0005616524,0.0001777716,0.0003095946,0.0002212247],"domain_scores_gemma":[0.9988919,0.00005480052,0.0004907976,0.0002561642,0.0001726094,0.0001337265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00155653,0.0001617431,0.0007177147,0.00002211857,0.000058554,0.000008943361,0.003578248,5.316886e-7,0.9929851,0.00002734871,0.000525022,0.0003581855],"study_design_scores_gemma":[0.002127879,0.002346888,0.0007160114,0.0002721636,0.00001586147,0.00004124788,0.003588494,0.000007927149,0.9902664,0.0000351302,0.000455918,0.0001260215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951732,0.003070293,0.00002176077,0.0007675599,0.0002896349,0.0006025441,0.00001596572,0.000003192607,0.00005584662],"genre_scores_gemma":[0.9987472,0.0005670115,0.0000948639,0.0000964408,0.0003197925,0.00001801437,0.000009539885,0.00002148045,0.0001256814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003573973,"threshold_uncertainty_score":0.4893241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01590358727249661,"score_gpt":0.2622320888387877,"score_spread":0.2463285015662911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}