{"id":"W2125053565","doi":"10.1074/jbc.m109.067207","title":"GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a β-Arrestin 1-mediated ERK1/2 Activation in Pancreatic β-Cells","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Institut National de la Santé et de la Recherche Médicale","keywords":"Phosphorylation; Cell biology; Signal transduction; Mitogen-Activated Protein Kinase 3; Protein kinase A; Kinase; Arrestin; Scaffold protein; Small interfering RNA; Biology; Beta cell; Chemistry; G protein-coupled receptor; Endocrinology; Biochemistry; Transfection; Insulin; Islet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004692923,0.0002160693,0.0006675667,0.00003806598,0.00003659829,0.00001850379,0.0001024468,0.0002756956,0.0003446609],"category_scores_gemma":[0.003214486,0.0001388581,0.0001505737,0.0002869466,0.00007516705,0.00009597756,0.00001391622,0.0005108613,0.00001287901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001125176,"about_ca_system_score_gemma":0.00006113471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006381399,"about_ca_topic_score_gemma":3.272575e-8,"domain_scores_codex":[0.9985186,0.00007749325,0.0006396116,0.0002004228,0.0002748225,0.0002890895],"domain_scores_gemma":[0.9982567,0.0009396523,0.0004112725,0.0001269578,0.00009349046,0.0001718746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004766462,0.0002417762,0.04582988,0.00005974872,0.00003444645,0.00003476234,0.00003838757,0.000006198427,0.95085,8.237869e-7,0.001317566,0.001109731],"study_design_scores_gemma":[0.002810522,0.001071109,0.0318031,0.0005477268,0.00007020797,0.0000523915,0.00007251347,0.0001662819,0.9628704,0.0001287174,0.0002542674,0.0001528156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964566,0.0009543401,0.00007216932,0.0005412614,0.00007368395,0.0001357919,0.000004036064,0.00003318241,0.001728943],"genre_scores_gemma":[0.9981741,0.0002311277,0.0006325803,0.0005856991,0.0002393423,0.000003181993,0.00004518254,0.000008339389,0.00008039537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01402678,"threshold_uncertainty_score":0.5662467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01343005053638147,"score_gpt":0.257577830539774,"score_spread":0.2441477800033925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}