{"id":"W2125054419","doi":"10.1093/hmg/ddm217","title":"Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity","year":2007,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":389,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; University of Toronto; McMaster University; Cure Huntington's Disease Initiative","keywords":"Huntingtin; Polyglutamine tract; Biology; Huntingtin Protein; Cell biology; Endoplasmic reticulum; Endosome; Mutant; Biochemistry; Intracellular; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006923854,0.0001882269,0.0001813048,0.00009177484,0.0001249495,0.0002425143,0.00009414581,0.0002031021,0.0005951404],"category_scores_gemma":[0.0001064088,0.00006630666,0.00008298382,0.0001172516,0.000119941,0.0001470209,0.0001147423,0.000184009,0.0002226521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002451824,"about_ca_system_score_gemma":0.00005948557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002442854,"about_ca_topic_score_gemma":0.0005622464,"domain_scores_codex":[0.9999553,0.000007271918,0.000003421945,0.000006292888,0.00001565649,0.00001200637],"domain_scores_gemma":[0.9999552,0.000008025295,0.0000108118,0.000003657638,0.000006091568,0.00001619286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008959537,0.00001656449,0.0003719383,0.00002136791,0.000004484073,0.0001795362,0.00001607673,0.00005186896,0.9967132,0.00009599391,0.0000456382,0.002393714],"study_design_scores_gemma":[0.00003444075,0.0006783552,0.0308298,0.00001674436,0.00003862268,0.001745173,0.00005415372,0.001094717,0.9582921,0.0002706454,0.006934311,0.00001099722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944605,0.003420073,0.0005424316,0.00006172271,0.0000201062,0.000007869451,0.000063019,0.00002810155,0.001396178],"genre_scores_gemma":[0.9960239,0.00166893,0.0004546117,0.00004346163,0.00001286474,0.00000929918,0.0001781721,0.000006579985,0.001602246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005951404,"threshold_uncertainty_score":0.001990974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02642567496643303,"score_gpt":0.2475578439840799,"score_spread":0.2211321690176469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}