{"id":"W2125065305","doi":"10.1128/jvi.01238-15","title":"Hemagglutinin-Neuraminidase Balance Influences the Virulence Phenotype of a Recombinant H5N3 Influenza A Virus Possessing a Polybasic HA <sub>0</sub> Cleavage Site","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; Canadian Food Inspection Agency","funders":"","keywords":"Biology; Virulence; Neuraminidase; Virology; Virus; Influenza A virus subtype H5N1; Nonsynonymous substitution; Influenza A virus; Reverse genetics; Cleavage (geology); Orthomyxoviridae; Gene; H5N1 genetic structure; Viral shedding; Microbiology; Genetics; Mutant; Genome; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001629965,0.0002575426,0.0001082099,0.00009432921,0.0001288547,0.0002455661,0.0001783225,0.0002577917,0.0007387851],"category_scores_gemma":[0.0001248375,0.00007464963,0.0001424568,0.00005764423,0.0002168743,0.0001310534,0.0001295284,0.000382791,0.0002234745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000347782,"about_ca_system_score_gemma":0.0001400631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009485938,"about_ca_topic_score_gemma":0.0008750682,"domain_scores_codex":[0.9998863,0.0000285051,0.0000109292,0.00002528725,0.0000231948,0.00002565594],"domain_scores_gemma":[0.9998273,0.00006022646,0.00003530288,0.00001354132,0.00001944353,0.00004420197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006949973,0.00001978871,0.0006066975,0.000005451676,0.000002531378,0.00001894993,0.00001184153,0.00001860373,0.9990093,0.00001138719,0.000004278143,0.0002216157],"study_design_scores_gemma":[0.00002186976,0.001185635,0.0346746,0.000006253875,0.00002965419,0.0004650906,0.00009017203,0.001393841,0.9615514,0.00002933326,0.0005453815,0.000006698674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996239,0.00006275095,0.0001340845,0.000005161425,0.000002462743,0.000003062339,0.00002680335,0.000004443405,0.0001372363],"genre_scores_gemma":[0.9992521,0.00003829095,0.000351985,0.00001004031,0.000001954709,0.000004347094,0.0001158441,0.000005995597,0.0002194541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009485938,"threshold_uncertainty_score":0.002523303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09349422768155927,"score_gpt":0.3745492893153564,"score_spread":0.2810550616337971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}