{"id":"W2125073987","doi":"10.1101/gad.236349.113","title":"Insights into the biological functions of Dock family guanine nucleotide exchange factors","year":2014,"lang":"en","type":"article","venue":"Genes & Development","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Fondation du cancer du sein du Québec; Cancer Research Society","keywords":"DOCK; Guanine nucleotide exchange factor; Biology; CDC42; GTPase; Morphogenesis; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003112665,0.0002533442,0.0003102586,0.0005331447,0.0002214029,0.0006541717,0.000214437,0.0003406224,0.0005256875],"category_scores_gemma":[0.0001654766,0.00009835811,0.0002362419,0.0002487848,0.0004946603,0.0006985029,0.0003292089,0.000776246,0.00026848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005180728,"about_ca_system_score_gemma":0.0003246846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005364985,"about_ca_topic_score_gemma":0.0005746901,"domain_scores_codex":[0.9999204,0.00001426854,0.000006281978,0.00001335084,0.00002522737,0.0000203631],"domain_scores_gemma":[0.9999585,0.00001105574,0.00000571115,0.000004490156,0.000008548371,0.0000116154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004993607,0.00006504862,0.00167454,0.001003498,0.00004164779,0.001984838,0.0002247164,0.002741198,0.8235537,0.05238299,0.001259021,0.1145695],"study_design_scores_gemma":[0.00007581908,0.0004373989,0.02614897,0.0003452855,0.0001817219,0.01044719,0.0008885549,0.007901083,0.5030547,0.05050838,0.3999256,0.00008533718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3142697,0.6361775,0.02162334,0.004683338,0.00034786,0.00001629866,0.0003136731,0.0001427886,0.02242537],"genre_scores_gemma":[0.6875741,0.3015829,0.005746186,0.0006473538,0.0001765116,0.00001095941,0.0002209605,0.00001445088,0.004026552],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0006541717,"threshold_uncertainty_score":0.003758848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0203276059176112,"score_gpt":0.2320799711341991,"score_spread":0.2117523652165879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}