{"id":"W2125094932","doi":"10.1186/s12977-014-0129-1","title":"The highly polymorphic cyclophilin A-binding loop in HIV-1 capsid modulates viral resistance to MxB","year":2015,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université du Québec à Montréal; Jewish General Hospital","funders":"National Institutes of Health; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Cypa; Capsid; Cyclophilin A; Virology; Biology; Mutation; Viral replication; Amino acid; V3 loop; Phenotype; Genetics; Virus; Molecular biology; Peptide sequence; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005136442,0.00009870595,0.0000702593,0.00009781898,0.00009194846,0.0001667903,0.0001026827,0.0001551539,0.0009054043],"category_scores_gemma":[0.0001016834,0.00005683513,0.00009473107,0.00005546041,0.0001398434,0.00006980224,0.00008700021,0.0001981494,0.0001136688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001418534,"about_ca_system_score_gemma":0.00006606814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004018538,"about_ca_topic_score_gemma":0.0005451995,"domain_scores_codex":[0.9999502,0.000009779246,0.000002614781,0.000009407759,0.00001288567,0.00001519979],"domain_scores_gemma":[0.9999249,0.00001665019,0.00002616088,0.000006357894,0.000006876403,0.00001905269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004885727,0.000009926996,0.001557665,0.000008579948,0.000003796571,0.00006033585,0.00001012545,0.00004740971,0.9978173,0.00002967809,0.00001870078,0.0003875002],"study_design_scores_gemma":[0.00002171204,0.0004590668,0.1194302,0.00001354012,0.00004734195,0.001648884,0.00009620425,0.003552541,0.8732066,0.0001299235,0.001381686,0.00001223425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994621,0.0001298768,0.0001344332,0.00001172498,0.00000158075,0.000002804319,0.00002929448,0.000004245969,0.0002240257],"genre_scores_gemma":[0.9996444,0.00004830171,0.0001419467,0.000009441195,0.000001245163,0.000001847861,0.0000414065,0.000002050677,0.0001093388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009054043,"threshold_uncertainty_score":0.00302887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652669800236984,"score_gpt":0.2531328555665941,"score_spread":0.2366061575642243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}