{"id":"W2125103450","doi":"10.1007/s11102-014-0585-6","title":"Pasireotide LAR maintains inhibition of GH and IGF-1 in patients with acromegaly for up to 25 months: results from the blinded extension phase of a randomized, double-blind, multicenter, Phase III study","year":2014,"lang":"en","type":"article","venue":"Pituitary","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"Novartis Pharma; Novartis Pharmaceuticals Corporation","keywords":"Pasireotide; Acromegaly; Medicine; Octreotide; Internal medicine; Gastroenterology; Somatostatin; Endocrinology; Urology; Growth hormone; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007224149,0.0002458941,0.0009339508,0.0001751142,0.00007647413,0.00001012727,0.00007629406,0.00006116663,0.000006735209],"category_scores_gemma":[0.0003269032,0.000145399,0.000122628,0.0001811491,0.00009654235,0.000134856,0.00006038503,0.0001059799,0.000001256996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003335941,"about_ca_system_score_gemma":0.00003888642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002677213,"about_ca_topic_score_gemma":0.001143379,"domain_scores_codex":[0.9980464,0.000150483,0.0007807176,0.0004351285,0.0003351932,0.0002520842],"domain_scores_gemma":[0.998418,0.0005093368,0.0002763194,0.0004427825,0.0002150835,0.0001385025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9542882,0.01041409,0.02616746,0.00004103157,0.0004238138,0.00001810171,0.004289032,0.00001544979,0.0001582114,0.00001725754,0.0001372107,0.004030079],"study_design_scores_gemma":[0.9460498,0.006353409,0.04352443,0.000328124,0.0007263819,8.273179e-7,0.001605541,0.0005501871,0.0005057523,0.0001884094,0.00002306188,0.0001440834],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908386,0.0001650344,0.0006186927,0.0003499805,0.00007751875,0.007424899,0.0004548362,0.00001582801,0.00005458082],"genre_scores_gemma":[0.9982377,0.00002705913,0.0004672109,0.0002126875,0.0000372736,0.0002618619,0.0007128961,0.00002360867,0.00001964374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01735697,"threshold_uncertainty_score":0.5929198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02962309875478429,"score_gpt":0.3144727975827402,"score_spread":0.2848496988279559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}