{"id":"W2125103450","doi":"10.1007/s11102-014-0585-6","title":"Pasireotide LAR maintains inhibition of GH and IGF-1 in patients with acromegaly for up to 25 months: results from the blinded extension phase of a randomized, double-blind, multicenter, Phase III study","year":2014,"lang":"en","type":"article","venue":"Pituitary","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"Novartis Pharma; Novartis Pharmaceuticals Corporation","keywords":"Pasireotide; Acromegaly; Medicine; Octreotide; Internal medicine; Gastroenterology; Somatostatin; Endocrinology; Urology; Growth hormone; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003120623,0.0008028009,0.001376811,0.0002242448,0.0003009114,0.0004676018,0.0004073424,0.0005309423,0.001416337],"category_scores_gemma":[0.001352826,0.0002666026,0.0008823802,0.0001801094,0.0005716411,0.0005488063,0.0002132882,0.001255027,0.0002766066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003991176,"about_ca_system_score_gemma":0.0008707411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005020218,"about_ca_topic_score_gemma":0.001397046,"domain_scores_codex":[0.99925,0.0004236979,0.00005470551,0.0000855285,0.00009344139,0.00009268575],"domain_scores_gemma":[0.9987079,0.0002985876,0.0003746342,0.0001241558,0.0001127076,0.0003819408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7295471,0.04791853,0.01151956,0.0006483792,0.001307573,0.0001900906,0.0002692969,0.0009577078,0.08052242,0.0001413882,0.001713782,0.1252643],"study_design_scores_gemma":[0.398347,0.5618759,0.0283762,0.00004861174,0.0005468054,0.0003338977,0.0000464261,0.0008832423,0.007820181,0.00008513354,0.001609008,0.00002738463],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969267,0.00134521,0.0003226302,0.00007966419,0.00004018807,0.0006167366,0.0001512159,0.00004006542,0.0004776375],"genre_scores_gemma":[0.9963771,0.0006422037,0.00119408,0.0002211309,0.00009624309,0.0005403328,0.0004286398,0.000008996059,0.0004913862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003120623,"threshold_uncertainty_score":0.01650357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02962309875478429,"score_gpt":0.3144727975827402,"score_spread":0.2848496988279559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}