{"id":"W2125116394","doi":"10.1093/nar/gkn919","title":"Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression","year":2008,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Department of Biotechnology, Ministry of Science and Technology, India; University of Oxford","keywords":"Biology; Chromatin immunoprecipitation; Nuclease; Molecular biology; Chromatin; Luciferase; Promoter; Immunoprecipitation; G-quadruplex; Hypersensitive site; DNA; Cell biology; Gene; Gene expression; Transfection; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007144787,0.0003261987,0.0003188787,0.0002627622,0.0005485383,0.00007450276,0.0002992478,0.0002346721,0.00004672815],"category_scores_gemma":[0.0002408973,0.000238262,0.0001359131,0.0003884596,0.0005826124,0.00004003602,0.0003262439,0.0005330383,0.00003028761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001103591,"about_ca_system_score_gemma":0.0001342103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000791935,"about_ca_topic_score_gemma":0.00004565256,"domain_scores_codex":[0.9968138,0.000504312,0.0003702379,0.0008607165,0.0008302479,0.0006206955],"domain_scores_gemma":[0.9982574,0.00005007389,0.0001607747,0.0006939171,0.000616866,0.0002209692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008823271,0.0002897908,0.0003552659,0.00002101741,0.000128959,0.0001132472,0.0002929612,0.000009211381,0.9925075,0.00001538877,0.003777056,0.001607293],"study_design_scores_gemma":[0.0005684721,0.00118298,0.0004761444,0.00009787398,0.00003482066,0.0001694807,0.001908981,0.0001309377,0.9853072,0.00002495029,0.009764451,0.0003337378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972927,0.00008136059,0.0003718052,0.0003335855,0.00004936136,0.0004944346,0.00005465205,0.00008362184,0.001238491],"genre_scores_gemma":[0.9887597,0.000169566,0.009525334,0.0001548529,0.000250986,0.00004657699,0.0002401113,0.00006391475,0.0007889909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009153528,"threshold_uncertainty_score":0.9716043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04624471382436895,"score_gpt":0.3453712800559035,"score_spread":0.2991265662315345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}