{"id":"W2125128437","doi":"10.1086/319291","title":"Spontaneous Mutations in the CsrRS Two‐Component Regulatory System of<i>Streptococcus pyogenes</i>Result in Enhanced Virulence in a Murine Model of Skin and Soft Tissue Infection","year":2001,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; U.S. Public Health Service; National Institutes of Health; University of Toronto; Emory University","keywords":"Virulence; Complementation; Streptococcus pyogenes; Microbiology; Biology; Streptococcus intermedius; Mutant; Bacteria; Streptococcus; Gene; Genetics; Staphylococcus aureus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002278368,0.0004558418,0.0002507386,0.0003184115,0.0001303218,0.0002153985,0.0001712649,0.0002815773,0.0009097033],"category_scores_gemma":[0.0001870611,0.0001782854,0.000295559,0.0001225031,0.0002723111,0.0001093686,0.0001378619,0.0006245137,0.00030133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003648159,"about_ca_system_score_gemma":0.000204193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004361957,"about_ca_topic_score_gemma":0.0005933291,"domain_scores_codex":[0.9996597,0.00009300095,0.00003559708,0.00005197186,0.00008221045,0.00007750154],"domain_scores_gemma":[0.9997603,0.00003509474,0.00009316763,0.00003193902,0.00001234058,0.00006710209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001149415,0.00007078073,0.0003283397,0.00001072844,0.000003696438,0.00004962685,0.00000563818,0.0000540109,0.9988114,0.00005323859,0.0000246384,0.0004730656],"study_design_scores_gemma":[0.00003394255,0.001698405,0.00608525,0.000006799005,0.00001759798,0.000841859,0.00001865832,0.001212962,0.9893784,0.00003579991,0.000664771,0.000005570241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984006,0.0001650278,0.0008126806,0.00003130642,0.000009298783,0.00001946019,0.0001129981,0.00004864725,0.00039995],"genre_scores_gemma":[0.9971895,0.0001241176,0.001514325,0.0000249941,0.000006135258,0.00002789418,0.0003324662,0.00001907865,0.0007614015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009097033,"threshold_uncertainty_score":0.003043294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01152007693336208,"score_gpt":0.2763146672414835,"score_spread":0.2647945903081214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}