{"id":"W2125160586","doi":"10.1067/mcp.2000.107047","title":"Population pharmacokinetics of long-term oral amiodarone therapy","year":2000,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"","keywords":"Pharmacokinetics; Bioavailability; Dosing; Regimen; Amiodarone; Medicine; Population; Discontinuation; NONMEM; Pharmacology; Half-life; Elimination rate constant; Internal medicine; Volume of distribution; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003299725,0.0003046208,0.0005736344,0.0002389553,0.0001227072,0.0007068723,0.0003983334,0.0004606891,0.0006913804],"category_scores_gemma":[0.007864188,0.0002010682,0.0005764757,0.0002072893,0.0002105734,0.0004648414,0.0002910028,0.0006717389,0.0001558537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005666515,"about_ca_system_score_gemma":0.0004538327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008000908,"about_ca_topic_score_gemma":0.0005022424,"domain_scores_codex":[0.9988927,0.0005955296,0.0000518272,0.0001912413,0.000212542,0.00005618406],"domain_scores_gemma":[0.996051,0.00264668,0.0006452474,0.0002898097,0.000258347,0.0001089271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005239089,0.000486138,0.6155966,0.0003465963,0.0035434,0.001083794,0.0008749682,0.2027335,0.02621015,0.003691287,0.002343205,0.1378513],"study_design_scores_gemma":[0.0002885522,0.005230904,0.5254314,0.00006839205,0.001461627,0.003215839,0.0001844106,0.4440186,0.007147044,0.005951861,0.00689937,0.0001020088],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9390839,0.002509926,0.05580808,0.0003282742,0.0000157609,0.00008045288,0.0005890045,0.0002235154,0.001361225],"genre_scores_gemma":[0.9959518,0.0003039557,0.002968406,0.00005996761,0.00001493687,0.00007038551,0.0004594589,0.00001160832,0.0001594084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003299725,"threshold_uncertainty_score":0.01745081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07404740526852116,"score_gpt":0.4350668760453905,"score_spread":0.3610194707768693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}