{"id":"W2125178416","doi":"10.2337/db10-0281","title":"FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction","year":2010,"lang":"en","type":"article","venue":"Diabetes","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Servier; Association Nationale de la Recherche et de la Technologie; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; GlaxoSmithKline","keywords":"Endocrinology; Internal medicine; Lipogenesis; Skeletal muscle; Type 2 diabetes; Insulin; Myogenesis; Thiazolidinedione; Rosiglitazone; Insulin resistance; Glucose uptake; Myocyte; Diabetes mellitus; Biology; Medicine; Lipid metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001883957,0.0004764189,0.0003010793,0.000343621,0.0002281531,0.0003058544,0.0001441574,0.0002950148,0.001031614],"category_scores_gemma":[0.0001584988,0.0001301072,0.0003805116,0.0003137534,0.000231303,0.0001550093,0.0001886265,0.0003281838,0.0002192258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002878598,"about_ca_system_score_gemma":0.0001187387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007348053,"about_ca_topic_score_gemma":0.001063621,"domain_scores_codex":[0.9998229,0.00001603399,0.00001785278,0.00006079269,0.00004921983,0.00003312951],"domain_scores_gemma":[0.9998318,0.00001685244,0.00008826403,0.00001062322,0.0000159918,0.00003637261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003393958,0.00002182893,0.004120716,0.00007704549,0.00002237452,0.0001737648,0.00001974963,0.0000199977,0.9937878,0.00002196293,0.00004444209,0.001350992],"study_design_scores_gemma":[0.0001092147,0.001144612,0.3681093,0.00008595071,0.0002192001,0.003235716,0.0002374677,0.0006353708,0.621366,0.0001412343,0.004694995,0.00002097967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892828,0.006768297,0.002287782,0.0001383046,0.00007584341,0.0000195305,0.0006208803,0.0000659696,0.0007405694],"genre_scores_gemma":[0.9934903,0.002432202,0.001473563,0.00008413938,0.0000549382,0.00003583974,0.0008957871,0.00001557699,0.001517558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001031614,"threshold_uncertainty_score":0.003451049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007881760645619374,"score_gpt":0.2262425022101149,"score_spread":0.2183607415644955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}