{"id":"W2125178416","doi":"10.2337/db10-0281","title":"FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction","year":2010,"lang":"en","type":"article","venue":"Diabetes","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Servier; Association Nationale de la Recherche et de la Technologie; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; GlaxoSmithKline","keywords":"Endocrinology; Internal medicine; Lipogenesis; Skeletal muscle; Type 2 diabetes; Insulin; Myogenesis; Thiazolidinedione; Rosiglitazone; Insulin resistance; Glucose uptake; Myocyte; Diabetes mellitus; Biology; Medicine; Lipid metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791782,0.0001921421,0.0003104036,0.0002790709,0.00009657739,0.00004413936,0.00004026357,0.0001256588,0.00004710225],"category_scores_gemma":[0.0008723847,0.0001698516,0.00002159546,0.0002505529,0.00008705131,0.0003860894,0.00004140838,0.0001586729,0.000001985631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001385773,"about_ca_system_score_gemma":0.00005393642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007953289,"about_ca_topic_score_gemma":0.00005182664,"domain_scores_codex":[0.9987959,0.00005870984,0.0003032871,0.0004170833,0.0001738837,0.0002510941],"domain_scores_gemma":[0.9994299,0.00007743225,0.00009851053,0.0001444828,0.00009628046,0.0001533733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008126591,0.00007080702,0.2382548,0.0002578638,0.00001706419,9.79076e-7,0.0006022979,0.000002282645,0.7576882,0.000004242562,0.00002950679,0.002990691],"study_design_scores_gemma":[0.0009241914,0.00005049083,0.4817832,0.0003630785,0.0000402271,7.130204e-7,0.00009167647,0.00008997423,0.5163149,0.00004903147,0.0001703605,0.0001221872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943069,0.004687302,1.499394e-7,0.0001466667,0.0003369203,0.0004535959,0.00001158945,0.0000381204,0.0000188173],"genre_scores_gemma":[0.9982929,0.0007557135,0.0001050011,0.00009326051,0.0005933268,0.00006398255,0.00002791062,0.00002079823,0.00004712354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2435284,"threshold_uncertainty_score":0.6926347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007881760645619374,"score_gpt":0.2262425022101149,"score_spread":0.2183607415644955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}