{"id":"W2125197680","doi":"10.1093/cvr/cvt048","title":"Over-expression of calpastatin aggravates cardiotoxicity induced by doxorubicin","year":2013,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Cardiotoxicity; Calpastatin; Doxorubicin; Pharmacology; Medicine; Cancer research; Internal medicine; Chemistry; Calpain; Toxicity; Chemotherapy; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001349081,0.0001394873,0.0002674315,0.0001130519,0.0001373373,0.00003549907,0.0001968468,0.0002329865,0.0001207984],"category_scores_gemma":[0.0003293327,0.00011978,0.0004571187,0.000274294,0.0001624758,0.000008896248,0.0001938103,0.0002314223,0.00004126329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000326791,"about_ca_system_score_gemma":0.00007350771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005421182,"about_ca_topic_score_gemma":0.000003505314,"domain_scores_codex":[0.9975775,0.0006204215,0.0002352202,0.000426879,0.0007929107,0.0003470894],"domain_scores_gemma":[0.998516,0.00003167766,0.00004626922,0.0007576583,0.0005007412,0.0001476418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003477083,0.00004086018,0.0003912791,0.00004091981,0.0001923866,9.536146e-7,0.00002426022,0.00006229271,0.9705563,0.000008940719,0.02125475,0.007392243],"study_design_scores_gemma":[0.0005824181,0.0001555868,0.004229589,0.0000288256,0.00001473998,0.000004038683,0.0001054283,0.00006990146,0.959873,0.00006186957,0.03473762,0.0001370115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926984,0.003254096,0.002041831,0.00005523874,0.00008576968,0.0007857147,0.00001463737,0.00001478721,0.001049522],"genre_scores_gemma":[0.9984068,0.0001873486,0.0001222226,0.00002021422,0.0001756021,0.0001484277,0.0001358113,0.00002773409,0.0007758366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01348287,"threshold_uncertainty_score":0.4884487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02636087894561251,"score_gpt":0.3008863637138595,"score_spread":0.274525484768247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}