{"id":"W2125211913","doi":"10.1158/0008-5472.can-06-1098","title":"A Novel Orally Active Small Molecule Potently Induces G1 Arrest in Primary Myeloma Cells and Prevents Tumor Growth by Specific Inhibition of Cyclin-Dependent Kinase 4/6","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":222,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Cyclin-dependent kinase 6; Cancer research; Multiple myeloma; Bone marrow; Palbociclib; Biology; Cyclin; Cell cycle; Cyclin D; Cell cycle checkpoint; Apoptosis; Cyclin D1; Cancer; Medicine; Immunology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005263943,0.0002156564,0.0003918963,0.0004840243,0.0000964652,0.00004402806,0.0001472815,0.0001077637,0.00007691867],"category_scores_gemma":[0.00007256669,0.0001911865,0.00006221577,0.0005564679,0.0002890953,0.0001429929,0.00019176,0.0006094488,0.00001621359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007276315,"about_ca_system_score_gemma":0.0004787755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006267535,"about_ca_topic_score_gemma":0.0005296819,"domain_scores_codex":[0.9970162,0.0002016608,0.0003922783,0.0005941291,0.001080263,0.0007154648],"domain_scores_gemma":[0.9988296,0.0001453836,0.0001008826,0.0002854427,0.0003472276,0.0002914358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002012862,0.001543315,0.01161884,0.000351689,0.00005829498,0.0005605847,0.0001105783,0.000002660467,0.9783438,0.00002588136,0.0007713703,0.00460014],"study_design_scores_gemma":[0.005864219,0.0004675084,0.2041468,0.0004363504,0.00001250587,0.00001248841,0.0001158364,0.00001553554,0.7885993,0.0001203625,0.00007470739,0.0001343906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949977,0.001270503,0.00003019952,0.0003508074,0.00004857306,0.001531478,0.0003500638,0.00001650798,0.00140417],"genre_scores_gemma":[0.9976096,0.0005938586,0.0003158286,0.00003983225,0.0001159602,0.0003179764,0.0001842049,0.00004211622,0.000780632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.192528,"threshold_uncertainty_score":0.947468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04171200528201956,"score_gpt":0.3253768174063412,"score_spread":0.2836648121243216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}