{"id":"W2125223264","doi":"10.1067/mcp.2000.104642","title":"Prediction of cyclosporine clearance in liver transplant recipients by the use of midazolam as a cytochrome P450 3A probe","year":2000,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-Luc","funders":"","keywords":"Midazolam; CYP3A; Ciclosporin; Pharmacokinetics; Pharmacology; Drug interaction; Trough level; Chemistry; Oral administration; Cytochrome P450; Transplantation; Medicine; Internal medicine; Metabolism; Tacrolimus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008154833,0.0003148249,0.0003234646,0.0003943866,0.0001695882,0.0003453837,0.0001182331,0.000248343,0.0005970232],"category_scores_gemma":[0.00248736,0.0001397614,0.0002040218,0.000166867,0.0001722894,0.0001953203,0.0001310715,0.0003700707,0.0002487999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002772815,"about_ca_system_score_gemma":0.0001443185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000374799,"about_ca_topic_score_gemma":0.0003608082,"domain_scores_codex":[0.9997467,0.0001010386,0.00002303427,0.00003014423,0.00007263343,0.00002652935],"domain_scores_gemma":[0.9986473,0.0006040573,0.0004155577,0.00006023735,0.0001142129,0.0001586992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003087511,0.0001453928,0.9751297,0.0000151574,0.00005732305,0.0001645764,0.00004718175,0.0007915995,0.00843757,0.00001338744,0.00009278699,0.01201785],"study_design_scores_gemma":[0.0001124773,0.004494364,0.9737612,0.00000828364,0.00008244813,0.00134692,0.00006635099,0.00937506,0.01034219,0.00004931553,0.0003475744,0.00001384526],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992599,0.0002259772,0.0003817931,0.00001358022,0.00000188608,0.000004812579,0.00002442566,0.000007464859,0.00008012235],"genre_scores_gemma":[0.9995474,0.00006632575,0.000271739,0.00001024229,0.000004436418,0.000005441292,0.00005393068,0.00000153497,0.00003891838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008154833,"threshold_uncertainty_score":0.004312754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1649591529415201,"score_gpt":0.3998444503930716,"score_spread":0.2348852974515516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}