{"id":"W2125238675","doi":"10.1086/429391","title":"Variation in Antiviral 2′,5′-Oligoadenylate Synthetase (2′5′AS) Enzyme Activity Is Controlled by a Single-Nucleotide Polymorphism at a Splice-Acceptor Site in the OAS1 Gene","year":2005,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":166,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; Gene; Molecular biology; Allele; Single-nucleotide polymorphism; Genetics; Enzyme; Genotype; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000491945,0.0007453873,0.0005470231,0.001182125,0.0002995912,0.0004329869,0.0002970837,0.0006554624,0.001651062],"category_scores_gemma":[0.0005494624,0.0002868311,0.0005358921,0.0005655885,0.0004932186,0.0001422749,0.0002429235,0.0006313033,0.000323766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002453938,"about_ca_system_score_gemma":0.0001448078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009000988,"about_ca_topic_score_gemma":0.001145084,"domain_scores_codex":[0.9991774,0.0002944977,0.0001064873,0.0002410157,0.0001064489,0.00007405001],"domain_scores_gemma":[0.9989707,0.0004547449,0.0002710226,0.0000695757,0.00005471188,0.0001792909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003163994,0.00018834,0.05037046,0.00006465149,0.0003588341,0.001299368,0.0003691038,0.0004251561,0.9386521,0.0004839823,0.0001417217,0.00448232],"study_design_scores_gemma":[0.000391553,0.001515644,0.8666444,0.00006416468,0.0006021679,0.007502234,0.000308404,0.004435771,0.1161346,0.0006515086,0.001648714,0.0001009111],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991316,0.0001112842,0.0003957357,0.00002249323,0.00001404769,0.00000552654,0.0001378528,0.00001250809,0.000168875],"genre_scores_gemma":[0.9991441,0.00004926833,0.0003601385,0.00002416978,0.00001203846,0.000005245704,0.000166981,0.00001710981,0.0002209121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001651062,"threshold_uncertainty_score":0.005523324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01800956148619646,"score_gpt":0.3023659024553841,"score_spread":0.2843563409691876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}