{"id":"W2125281277","doi":"10.1074/mcp.m800007-mcp200","title":"Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease","year":2008,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of Washington; University of California, Los Angeles; Yale University","keywords":"Alzheimer's disease; Neuroscience; Disease; Caspase; Apoptosis; Computational biology; Medicine; Biology; Internal medicine; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090691,0.0001694502,0.0001682677,0.00006740904,0.00008245955,0.000007283759,0.00009982915,0.0001267355,0.000006673842],"category_scores_gemma":[0.0000185261,0.0001778882,0.00008735801,0.00007757927,0.0001144363,0.00000527625,0.0001170647,0.00009814426,9.57388e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008015819,"about_ca_system_score_gemma":0.00005561254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000535205,"about_ca_topic_score_gemma":0.00001000777,"domain_scores_codex":[0.9990276,0.00008362869,0.0001875572,0.0003633361,0.0001313275,0.0002066083],"domain_scores_gemma":[0.9994012,0.000002774164,0.00009300683,0.0003469493,0.00003971222,0.0001164009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000650329,0.0001096613,0.001688287,0.00002044806,0.00002194836,0.000111351,0.00002851695,0.0003352602,0.9970258,0.0002715696,0.00001223727,0.0003098261],"study_design_scores_gemma":[0.0005241235,0.0001256932,0.009907645,0.000009199209,0.0000309414,0.00001372701,0.00000391868,0.0006715854,0.9879236,0.0002285344,0.0003712364,0.0001897977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988821,0.001798501,0.008669369,0.00005802595,0.00004093939,0.0004964351,0.00001135059,0.000007545358,0.00009688979],"genre_scores_gemma":[0.9982313,0.0001591182,0.001286157,0.00004424813,0.00003463493,0.00003026831,0.0000816931,0.00003245467,0.0001001619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00941032,"threshold_uncertainty_score":0.7254072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01287280602358518,"score_gpt":0.2268466706508973,"score_spread":0.2139738646273121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}