{"id":"W2125320515","doi":"10.1261/rna.5200204","title":"Eukaryotic protein synthesis inhibitors identified by comparison of cytotoxicity profiles","year":2004,"lang":"en","type":"article","venue":"RNA","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Cytotoxicity; Biology; Translation (biology); Protein biosynthesis; Biochemistry; Eukaryotic translation; In vivo; Computational biology; Function (biology); In vitro; Cell biology; Messenger RNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001775273,0.0001537961,0.0004227343,0.00008048194,0.00006164154,0.00001476892,0.0001067401,0.0001176082,0.0001551113],"category_scores_gemma":[0.0004011756,0.0001138878,0.0001113544,0.000217819,0.0001083163,0.00007034046,0.00003856481,0.0001780835,0.00005295499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000752013,"about_ca_system_score_gemma":0.00006694284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001904843,"about_ca_topic_score_gemma":0.000009130769,"domain_scores_codex":[0.9988369,0.00003447295,0.0003857355,0.000272267,0.0002585625,0.0002120977],"domain_scores_gemma":[0.9993543,0.00003288164,0.0001669695,0.0002643555,0.00009132354,0.0000901584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001183898,0.0003721365,0.0008294867,0.000327633,0.00004631443,0.000005052078,0.00009729043,0.000001438593,0.9913549,0.00005970557,0.004226536,0.002561113],"study_design_scores_gemma":[0.0002972459,0.0001208793,0.001973234,0.0006344745,0.00007558768,0.000005922574,0.00007423308,0.000004750566,0.996327,0.00006841573,0.0002907867,0.0001274094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959763,0.0005112647,0.00001896854,0.00207986,0.00008828031,0.0007477317,0.00003121293,0.00005717582,0.0004891471],"genre_scores_gemma":[0.9983165,0.00001131789,0.0007960399,0.00005986988,0.0001391223,0.000005170033,0.00001145779,0.00001888717,0.0006416123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004972157,"threshold_uncertainty_score":0.4644211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01687474114128532,"score_gpt":0.2627272824268839,"score_spread":0.2458525412855986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}