{"id":"W2125327426","doi":"10.1152/ajpheart.00011.2015","title":"Pyruvate modifies metabolic flux and nutrient sensing during extracorporeal membrane oxygenation in an immature swine model","year":2015,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Pacific Northwest National Laboratory; Biological and Environmental Research; National Heart, Lung, and Blood Institute; U.S. Department of Energy","keywords":"Pyruvate decarboxylation; Pyruvate carboxylase; Pyruvate kinase; Citric acid cycle; Gluconeogenesis; Pyruvate dehydrogenase kinase; Pyruvate dehydrogenase complex; Beta oxidation; Extracorporeal circulation; Glycolysis; Internal medicine; PKM2; Biochemistry; Chemistry; Flux (metallurgy); Extracorporeal membrane oxygenation; Metabolism; Endocrinology; Biology; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002453653,0.0004323724,0.0004197758,0.0001951,0.0001213099,0.0002673512,0.0003210987,0.0003332972,0.0005379235],"category_scores_gemma":[0.0001838812,0.0001626346,0.000274685,0.0001521608,0.0004407812,0.00037245,0.0001841305,0.0007554881,0.00009862109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873303,"about_ca_system_score_gemma":0.0003087628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004480063,"about_ca_topic_score_gemma":0.0006446366,"domain_scores_codex":[0.9998795,0.00002691564,0.000010701,0.00003472365,0.00001894171,0.0000291438],"domain_scores_gemma":[0.9997972,0.00002317372,0.00008056396,0.00002653198,0.0000173921,0.00005519893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002779104,0.0001909023,0.001191926,0.00004554592,0.00001052068,0.0001464849,0.00003821302,0.0001036875,0.9934815,0.0000587002,0.00003100812,0.001922358],"study_design_scores_gemma":[0.0002427087,0.01898531,0.02381799,0.00001756056,0.0001233223,0.0004597148,0.0001879391,0.002734036,0.9515721,0.0001771755,0.001654752,0.0000274655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985306,0.0002574091,0.0008936823,0.00003973171,0.00002180773,0.0000228212,0.0000771776,0.00001494902,0.0001417926],"genre_scores_gemma":[0.9962139,0.0005011386,0.001943505,0.00006562659,0.00001625133,0.00008232651,0.0003391666,0.00001145404,0.0008266482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005379235,"threshold_uncertainty_score":0.002084672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01967098228139092,"score_gpt":0.2556602472970785,"score_spread":0.2359892650156876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}