{"id":"W2125370994","doi":"10.1093/carcin/bgt003","title":"Early transformative changes in normal ovarian surface epithelium induced by oxidative stress require Akt upregulation, DNA damage and epithelial–stromal interaction","year":2013,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; University of Illinois at Urbana-Champaign","keywords":"Protein kinase B; PTEN; Downregulation and upregulation; Cancer research; Oxidative stress; Stromal cell; Biology; Malignant transformation; Tensin; Cell growth; DNA damage; Cell biology; PI3K/AKT/mTOR pathway; Chemistry; Endocrinology; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001329057,0.0002842692,0.0004136074,0.0001464437,0.0001039569,0.00006412007,0.00007643671,0.0001483164,0.0003184781],"category_scores_gemma":[0.00001810082,0.0002497938,0.00006597336,0.0002606301,0.00007108623,0.0006672891,0.00003280536,0.0001510607,0.00003143658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002256646,"about_ca_system_score_gemma":0.00006207376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003659324,"about_ca_topic_score_gemma":0.0004230309,"domain_scores_codex":[0.998548,0.0001304913,0.0003299813,0.0004059272,0.0002359484,0.0003496417],"domain_scores_gemma":[0.9991508,0.00009223157,0.0001327745,0.0002638795,0.0001622852,0.0001980348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004360327,0.000560996,0.4100123,0.0002244546,0.0003702846,0.00003644773,0.01299635,0.00002954139,0.5473957,0.0001444053,0.0002844944,0.02750892],"study_design_scores_gemma":[0.00196304,0.0004348329,0.6597021,0.0001478305,0.00009928286,0.000008008629,0.001145381,0.0001512673,0.3360499,0.00002420281,0.0001034776,0.0001706899],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936242,0.0002661313,0.00005865161,0.004099357,0.0001494809,0.001056168,0.0002760891,0.00004200801,0.0004279455],"genre_scores_gemma":[0.9988143,0.0001232253,0.0002444938,0.0002085901,0.0001042123,0.0001972488,0.0001374219,0.00003696412,0.0001334848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2496898,"threshold_uncertainty_score":0.9999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162999006769426,"score_gpt":0.2493948342490572,"score_spread":0.2330949335721146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}