{"id":"W2125370994","doi":"10.1093/carcin/bgt003","title":"Early transformative changes in normal ovarian surface epithelium induced by oxidative stress require Akt upregulation, DNA damage and epithelial–stromal interaction","year":2013,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; University of Illinois at Urbana-Champaign","keywords":"Protein kinase B; PTEN; Downregulation and upregulation; Cancer research; Oxidative stress; Stromal cell; Biology; Malignant transformation; Tensin; Cell growth; DNA damage; Cell biology; PI3K/AKT/mTOR pathway; Chemistry; Endocrinology; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008852119,0.0002443055,0.000182878,0.0002626274,0.0001933022,0.000339418,0.00009356184,0.0001905199,0.00163975],"category_scores_gemma":[0.00008550103,0.0001377818,0.0002902026,0.0001838752,0.0001913939,0.000267352,0.0002127072,0.0004587043,0.0002578692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002045309,"about_ca_system_score_gemma":0.0002003267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004381861,"about_ca_topic_score_gemma":0.0008404295,"domain_scores_codex":[0.9998587,0.000013184,0.0000145469,0.00002532807,0.00005394434,0.00003423908],"domain_scores_gemma":[0.9999087,0.00001206819,0.00002494092,0.00001308821,0.00001545735,0.00002574343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006824833,0.00002399824,0.000674646,0.000023163,0.000003304766,0.00006008253,0.00001700748,0.00001353846,0.9982469,0.00005983346,0.00001600297,0.0007932101],"study_design_scores_gemma":[0.000008949287,0.0002367858,0.03919598,0.000005993684,0.00001086926,0.0004074501,0.00010088,0.000439329,0.9571879,0.00007161214,0.002329009,0.000005289045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955797,0.001285424,0.001508952,0.000066863,0.00001682564,0.00002138109,0.0003216333,0.00003826963,0.001160965],"genre_scores_gemma":[0.9950604,0.0008206461,0.00109121,0.00003361659,0.000004448442,0.00002484457,0.0005952821,0.000007048968,0.002362268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00163975,"threshold_uncertainty_score":0.005485535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162999006769426,"score_gpt":0.2493948342490572,"score_spread":0.2330949335721146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}