{"id":"W2125415514","doi":"10.1074/jbc.m709221200","title":"Steroidogenic Activity of StAR Requires Contact with Mitochondrial VDAC1 and Phosphate Carrier Protein","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; March of Dimes Foundation; National Institutes of Health; Pfizer; American Heart Association; Howard Hughes Medical Institute","keywords":"VDAC1; Steroidogenic acute regulatory protein; Cholesterol side-chain cleavage enzyme; Inner mitochondrial membrane; Cell biology; Phosphorylation; Biology; Chemistry; Mitochondrion; Biochemistry; Gene expression; Bacterial outer membrane; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001202986,0.0001638562,0.0003389962,0.0000167757,0.00005459459,0.000006351355,0.00014033,0.000284594,0.00009209262],"category_scores_gemma":[0.0001803221,0.0001065508,0.0001245018,0.00005215776,0.0002566222,0.000007492527,0.00005836865,0.0002094696,5.207363e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001167009,"about_ca_system_score_gemma":0.0001162432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004842606,"about_ca_topic_score_gemma":0.000001553835,"domain_scores_codex":[0.9990573,0.00007654543,0.0003270784,0.000225411,0.0001374719,0.0001761819],"domain_scores_gemma":[0.999092,0.00002304552,0.0004031429,0.0001741091,0.0001685591,0.0001390725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0032588,0.00007868346,0.003022216,0.00002433904,0.00007958844,0.00005691967,0.00002326959,0.000002331284,0.9930207,0.000002591943,0.0002198651,0.0002107636],"study_design_scores_gemma":[0.001514119,0.001806933,0.002625261,0.00002611929,0.00002016404,0.0008745718,0.00003130113,0.000001672429,0.9889187,0.00001704501,0.00402743,0.0001366703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983572,0.0007643196,0.0003428226,0.00005753529,0.0001158106,0.0001166294,0.00002777677,0.000003944357,0.0002139276],"genre_scores_gemma":[0.997783,0.0002883141,0.001076312,0.00004839722,0.000453401,0.000004708696,0.00001012128,0.000009167912,0.000326585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004101919,"threshold_uncertainty_score":0.4345017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02107656150934727,"score_gpt":0.23623080008675,"score_spread":0.2151542385774028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}