{"id":"W2125428954","doi":"10.1002/cbic.200700266","title":"Strong Inhibition of Cholera Toxin by Multivalent GM1 Derivatives","year":2007,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Cholera toxin; Toxin; Chemistry; Ligand (biochemistry); Derivative (finance); Stereochemistry; Combinatorial chemistry; Oligosaccharide; Vibrio cholerae; Biophysics; Biochemistry; Microbiology; Biology; Receptor; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000216082,0.0001227304,0.0002152574,0.00006536495,0.00004048729,0.000005441202,0.00005707855,0.00008299273,0.0003493771],"category_scores_gemma":[0.00007058706,0.0001023636,0.00009385454,0.0001509963,0.000160395,0.00004355548,0.00005758803,0.0001792814,0.00002737931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004791363,"about_ca_system_score_gemma":0.00003417717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004106294,"about_ca_topic_score_gemma":0.000001199357,"domain_scores_codex":[0.9989138,0.000009678558,0.0002564711,0.0001990103,0.0003364451,0.0002846079],"domain_scores_gemma":[0.9994331,0.00006751624,0.00006617101,0.0001541434,0.000118609,0.0001604494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002992618,0.0002734048,0.004712596,0.0001685141,0.00004327349,0.00001422669,0.0003250571,1.413984e-7,0.9847865,0.0001771788,0.004193398,0.00500644],"study_design_scores_gemma":[0.0008959873,0.0001601775,0.02212789,0.0001160223,0.00001104659,0.00001113234,0.0002430599,0.0000204596,0.9664509,0.00002146823,0.009847572,0.00009423144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799528,0.00073774,0.0002784551,0.0008539623,0.00003353937,0.0001861412,0.00002375899,0.0000233082,0.01791031],"genre_scores_gemma":[0.9919161,0.00006463493,0.0006073095,0.0001837057,0.0001332902,0.000005179316,0.000119601,0.00001402046,0.006956192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01833556,"threshold_uncertainty_score":0.4174266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02783969089947008,"score_gpt":0.3305733577141642,"score_spread":0.3027336668146941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}