{"id":"W2125438399","doi":"10.1161/01.atv.0000154142.61859.94","title":"Glucosamine-Induced Endoplasmic Reticulum Stress Promotes ApoB100 Degradation","year":2004,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hospital for Sick Children; McMaster University Medical Centre","funders":"","keywords":"Endoplasmic reticulum; Unfolded protein response; Apolipoprotein B; Tunicamycin; Chemistry; Leupeptin; Protein degradation; Endoplasmic-reticulum-associated protein degradation; Lactacystin; Cell biology; Intracellular; Proteasome; Proteasome inhibitor; Biochemistry; Biology; Protease; Enzyme; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007783889,0.0004924078,0.0002511968,0.0001415954,0.0001174242,0.0002323467,0.0001150602,0.0002755049,0.001049099],"category_scores_gemma":[0.0000720957,0.00009655527,0.0002858325,0.0001321662,0.000195328,0.0001566119,0.0001730057,0.0003181466,0.000414039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00035718,"about_ca_system_score_gemma":0.000152861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008582821,"about_ca_topic_score_gemma":0.001089714,"domain_scores_codex":[0.999905,0.00001257433,0.000009461993,0.00001897213,0.00002791797,0.00002616183],"domain_scores_gemma":[0.9999491,0.000003206774,0.00002001035,0.000005338614,0.000009275887,0.00001298725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002111427,0.000019476,0.0002744081,0.0000527134,0.00000550318,0.0001158947,0.000009143797,0.00001743382,0.9985071,0.00001711495,0.0000209075,0.0007491813],"study_design_scores_gemma":[0.00003842891,0.0005305489,0.02234036,0.00001470693,0.00002284123,0.0007118987,0.00007139482,0.0004949182,0.9741668,0.00005138885,0.001549212,0.000007450664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956946,0.002132701,0.0008672687,0.00007842756,0.00002555092,0.00001976942,0.0002022987,0.00004316617,0.0009361711],"genre_scores_gemma":[0.9948185,0.001373451,0.001219629,0.00006672693,0.00001322123,0.00002701293,0.0003368707,0.00001025962,0.002134359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049099,"threshold_uncertainty_score":0.003509581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02052839607773767,"score_gpt":0.2651768956381237,"score_spread":0.2446484995603861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}