{"id":"W2125442413","doi":"10.1093/hmg/ddq501","title":"Bidirectional transcription stimulates expansion and contraction of expanded (CTG)•(CAG) repeats","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke","keywords":"Myotonic dystrophy; Biology; Trinucleotide repeat expansion; Transcription (linguistics); Tandem repeat; Genetics; Somatic cell; Genome instability; Gene; DNA; Genome; DNA damage; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007773875,0.0001734688,0.0001692533,0.0001186457,0.0001577089,0.00004185842,0.000113721,0.00008676245,0.00008264436],"category_scores_gemma":[0.000144438,0.0001827635,0.00007472322,0.000118335,0.0002068119,0.00005754083,0.0000314856,0.0001658142,0.000004808274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007592765,"about_ca_system_score_gemma":0.00003287423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009267865,"about_ca_topic_score_gemma":0.00001719306,"domain_scores_codex":[0.998615,0.0001364842,0.0002765675,0.0004586354,0.000328012,0.0001852541],"domain_scores_gemma":[0.9993088,0.00005320236,0.00011558,0.0003062841,0.0001034708,0.0001126798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002701571,0.0001130664,0.0009095508,0.00001519942,0.00000474489,0.000008687472,0.00009288722,0.0004557945,0.9959856,0.000852724,0.00001923707,0.001515466],"study_design_scores_gemma":[0.0005544228,0.0001544658,0.0602306,0.000009484093,0.00003580632,0.00002493328,0.00001344113,0.0007366136,0.9360221,0.001934937,0.0001251281,0.0001580571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998056,0.0001562182,0.0008614804,0.00003234773,0.0003099472,0.0002808038,0.00001843995,0.00004935871,0.0002353994],"genre_scores_gemma":[0.9990141,0.00007922071,0.0005848625,0.0001424731,0.00005420201,0.00001689987,0.000009895685,0.00003018034,0.00006821153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05996352,"threshold_uncertainty_score":0.7452881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02660559113871711,"score_gpt":0.284942322092995,"score_spread":0.2583367309542779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}