{"id":"W2125449720","doi":"10.1093/bja/aet038","title":"Potentiation of GABAA receptor activity by volatile anaesthetics is reduced by α5GABAA receptor-preferring inverse agonists","year":2013,"lang":"en","type":"article","venue":"British Journal of Anaesthesia","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Toronto Western Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Sevoflurane; Isoflurane; Long-term potentiation; GABAA receptor; Chemistry; Agonist; Inverse agonist; Pharmacology; Receptor; Anesthesia; Endocrinology; Internal medicine; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004883985,0.0002127047,0.0004146426,0.0002048141,0.0003021257,0.0002136522,0.0007798348,0.0001354974,0.0006351818],"category_scores_gemma":[0.0004542487,0.000238499,0.0001958767,0.0006068194,0.0004365545,0.001271313,0.00009614791,0.0007110253,0.00008513404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008012907,"about_ca_system_score_gemma":0.0001771245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000175258,"about_ca_topic_score_gemma":0.000002573289,"domain_scores_codex":[0.9969202,0.0005761369,0.0006287595,0.0004516933,0.0008957551,0.000527468],"domain_scores_gemma":[0.9982706,0.0001046106,0.00074467,0.0002337967,0.0002975525,0.0003487422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006349573,0.0002487736,0.000649713,0.000013037,0.000005556918,0.00007039695,0.00006845831,0.000004159216,0.8303818,0.000002155627,0.1287977,0.03969476],"study_design_scores_gemma":[0.0007250617,0.0007716239,0.002225883,0.00008321918,0.00001732581,0.0004319719,0.00003796882,0.0003773506,0.9873471,0.00004962237,0.007709898,0.0002229801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971762,0.0001727519,0.00003289385,0.001706631,0.0004086613,0.0002934936,0.0000527245,0.00002478825,0.0001317985],"genre_scores_gemma":[0.9938627,0.004209125,0.0001092673,0.0009946735,0.00006325478,0.000007697947,0.000001538216,0.00003990567,0.0007118661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1569653,"threshold_uncertainty_score":0.9725708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02494752141205205,"score_gpt":0.2764664061405857,"score_spread":0.2515188847285337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}