{"id":"W2125478648","doi":"10.1161/circresaha.108.193011","title":"Palmitoylation of ATP-Binding Cassette Transporter A1 Is Essential for Its Trafficking and Function","year":2009,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia","funders":"","keywords":"ABCA1; Palmitoylation; Lipid-anchored protein; Efflux; Endosome; Cell biology; Biochemistry; Transporter; Apolipoprotein B; Biology; ATP-binding cassette transporter; Transmembrane protein; Chemistry; Cholesterol; Enzyme; Intracellular; Cysteine; Autophagy; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002541251,0.000259138,0.0002904332,0.0002175967,0.0004624235,0.0005312807,0.0001746885,0.0004004394,0.001867625],"category_scores_gemma":[0.0005464491,0.0001872681,0.0001991651,0.0002146303,0.0002695048,0.0002865709,0.000355337,0.0004546946,0.001472267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005395236,"about_ca_system_score_gemma":0.0004236244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001163087,"about_ca_topic_score_gemma":0.0009484103,"domain_scores_codex":[0.9997622,0.00005460488,0.00003058194,0.00004178855,0.00006514342,0.00004556517],"domain_scores_gemma":[0.9996777,0.0000493238,0.0001046621,0.00004000878,0.00006755853,0.00006077018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003155435,0.00002947907,0.001931396,0.0001244453,0.00001379555,0.000373393,0.00002968255,0.0001466142,0.9872432,0.0005929098,0.0004449948,0.008754746],"study_design_scores_gemma":[0.00004461382,0.0001976941,0.04116725,0.00003651104,0.00004437259,0.002267923,0.0000844715,0.00188908,0.9233372,0.001005819,0.02990161,0.00002350474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758346,0.01274366,0.005979355,0.001154135,0.0001564846,0.0000340171,0.0006252184,0.0002248343,0.003247734],"genre_scores_gemma":[0.9901006,0.003048981,0.002074425,0.00009984178,0.00003901882,0.00002338731,0.0007055689,0.00003361285,0.003874626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001867625,"threshold_uncertainty_score":0.006247818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0887253577148686,"score_gpt":0.3863643210806031,"score_spread":0.2976389633657345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}