{"id":"W2125500226","doi":"10.1128/aac.48.9.3233-3240.2004","title":"Safety, Pharmacokinetics, Pharmacodynamics, and Plasma Lipoprotein Distribution of Eritoran (E5564) during Continuous Intravenous Infusion into Healthy Volunteers","year":2004,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pharmacokinetics; Pharmacodynamics; Pharmacology; Volume of distribution; Lipopolysaccharide; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001246317,0.0002148056,0.0002685926,0.00004076096,0.0001724446,0.00003050173,0.0001116188,0.0001313323,0.00001229732],"category_scores_gemma":[0.00001035359,0.000215634,0.00006244751,0.00007243608,0.0001522414,0.00001083988,0.00007965619,0.0001078808,7.758236e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002158462,"about_ca_system_score_gemma":0.0000400118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005747529,"about_ca_topic_score_gemma":0.00003659559,"domain_scores_codex":[0.9989302,0.00002883047,0.0003268713,0.0003470318,0.0001005421,0.0002665312],"domain_scores_gemma":[0.9995508,0.00000351608,0.0001272246,0.0001380747,0.00006856979,0.000111804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009621984,0.0001459726,0.001738413,0.0001292608,0.00007995166,0.000003378664,0.0004178463,0.0001237961,0.9837658,0.00002307287,0.0002253976,0.01238486],"study_design_scores_gemma":[0.008269668,0.0003002466,0.01469345,0.00008765332,0.00004518262,0.00004437031,0.00007817358,0.0001743195,0.9608433,0.00002909272,0.0150915,0.0003430285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973486,0.0003332809,0.0009924272,0.0006624614,0.0002515846,0.0003015262,0.00008048411,0.00001541262,0.00001421251],"genre_scores_gemma":[0.9876859,0.0103851,0.0004484234,0.0008483408,0.0003475637,0.000003819652,0.0002191474,0.00003091483,0.00003078314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02292255,"threshold_uncertainty_score":0.87933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003945194298483664,"score_gpt":0.2312243296506557,"score_spread":0.227279135352172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}