{"id":"W2125500226","doi":"10.1128/aac.48.9.3233-3240.2004","title":"Safety, Pharmacokinetics, Pharmacodynamics, and Plasma Lipoprotein Distribution of Eritoran (E5564) during Continuous Intravenous Infusion into Healthy Volunteers","year":2004,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pharmacokinetics; Pharmacodynamics; Pharmacology; Volume of distribution; Lipopolysaccharide; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003848407,0.0004841535,0.0006419937,0.0001213868,0.000163477,0.0004817882,0.0002008075,0.0004388798,0.0005223313],"category_scores_gemma":[0.000853355,0.0001699157,0.0001886555,0.0001335076,0.0003725581,0.0003279536,0.0001282587,0.0006580226,0.0003553439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001892193,"about_ca_system_score_gemma":0.000220724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003343022,"about_ca_topic_score_gemma":0.0001847914,"domain_scores_codex":[0.9997116,0.0001341542,0.00001405561,0.0000631456,0.0000422236,0.00003491098],"domain_scores_gemma":[0.999644,0.00008145561,0.0001341549,0.00003974602,0.00003019643,0.00007044033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.2205444,0.004649767,0.0218343,0.0003413416,0.0002929033,0.0009100225,0.0004867529,0.001525476,0.5784539,0.0001915878,0.001030059,0.1697394],"study_design_scores_gemma":[0.01078716,0.3697133,0.2048994,0.00009744507,0.0008234876,0.004680945,0.0003828403,0.01213079,0.3885598,0.0003690686,0.00743142,0.0001243117],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972802,0.000939607,0.001079892,0.00003835964,0.00001079625,0.00005731454,0.0001107619,0.0000900623,0.0003929526],"genre_scores_gemma":[0.9981433,0.0003839263,0.0006073703,0.00007325736,0.00003335011,0.000100509,0.0001497482,0.00001745787,0.0004910377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006419937,"threshold_uncertainty_score":0.00203526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003945194298483664,"score_gpt":0.2312243296506557,"score_spread":0.227279135352172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}