{"id":"W2125601510","doi":"10.1093/carcin/bgi009","title":"Methylation and inhibition of expression of uPA by the RAS oncogene: divergence of growth control and invasion in breast cancer cells","year":2004,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"DNA methylation; DNMT1; Transfection; Gene silencing; Biology; Methylation; Cancer research; DNA methyltransferase; Molecular biology; Ectopic expression; Oncogene; Cancer cell; Demethylating agent; Gene expression; Cancer; Cell culture; Cell; Cell cycle; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444254,0.0002891964,0.0003560009,0.0002244237,0.0001643526,0.000255974,0.0001839615,0.0002349908,0.0008581721],"category_scores_gemma":[0.0001426971,0.0002141506,0.0003615558,0.0002280313,0.0001582384,0.0001453293,0.0002306899,0.0005341081,0.0003808569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003192097,"about_ca_system_score_gemma":0.0002325158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069661,"about_ca_topic_score_gemma":0.001217481,"domain_scores_codex":[0.9997912,0.00003204191,0.00002517374,0.00002967572,0.00008343096,0.00003856155],"domain_scores_gemma":[0.9999006,0.00001939364,0.00002161133,0.00002239709,0.0000163314,0.00001977124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002909968,0.000006948315,0.00005067757,0.00001182851,0.000002556381,0.00001184597,0.000005506879,0.00002557877,0.9993364,0.0000280997,0.000006203946,0.0004852783],"study_design_scores_gemma":[0.000003815953,0.00008317718,0.001808501,0.000001793432,0.000007423419,0.0001319973,0.000009803905,0.0004896626,0.9961644,0.00001443251,0.001282588,0.000002393667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918255,0.003051131,0.003088581,0.0001110946,0.0000260232,0.00003342378,0.0004356796,0.00009066605,0.001337966],"genre_scores_gemma":[0.9913624,0.001577179,0.003046674,0.00003663772,0.000006830569,0.00005295611,0.0007809862,0.00001965536,0.003116623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001069661,"threshold_uncertainty_score":0.002870798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007527230892090521,"score_gpt":0.2275259713608159,"score_spread":0.2199987404687254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}