{"id":"W2125601510","doi":"10.1093/carcin/bgi009","title":"Methylation and inhibition of expression of uPA by the RAS oncogene: divergence of growth control and invasion in breast cancer cells","year":2004,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"DNA methylation; DNMT1; Transfection; Gene silencing; Biology; Methylation; Cancer research; DNA methyltransferase; Molecular biology; Ectopic expression; Oncogene; Cancer cell; Demethylating agent; Gene expression; Cancer; Cell culture; Cell; Cell cycle; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001999422,0.00008208839,0.0001441128,0.00004229288,0.00002628249,0.000002423149,0.00004511895,0.00009385405,0.00000276006],"category_scores_gemma":[0.00002121672,0.00006422117,0.00003189727,0.00009163671,0.0000979634,0.000006683131,0.00004567287,0.00002544636,4.153854e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009393539,"about_ca_system_score_gemma":0.00003610945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000522637,"about_ca_topic_score_gemma":0.00004131629,"domain_scores_codex":[0.9993371,0.00007286668,0.0002366777,0.0001698651,0.0001074974,0.0000760109],"domain_scores_gemma":[0.9995343,0.00002259636,0.0001738195,0.0001212403,0.0001194524,0.00002859403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009418144,0.00002806547,0.09281307,0.00005379314,0.000007291061,1.191796e-7,0.00009983113,0.0003028958,0.9052328,0.00001409618,0.000005641987,0.00134815],"study_design_scores_gemma":[0.0006966645,0.00006644309,0.1421391,0.00004274711,0.00002322416,4.797577e-7,0.00005191509,0.0000230441,0.8567575,0.0001379072,0.000006215733,0.0000547361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892057,0.008892862,0.001494803,0.00008477286,0.00002848428,0.0001611979,0.0001212328,9.600441e-7,0.00001001021],"genre_scores_gemma":[0.9953347,0.004479969,0.0001086383,0.00001784003,0.00001795352,0.00001033416,0.00002037931,0.000007362892,0.000002865369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04932603,"threshold_uncertainty_score":0.2618863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007527230892090521,"score_gpt":0.2275259713608159,"score_spread":0.2199987404687254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}