{"id":"W2125610771","doi":"10.3324/haematol.11755","title":"Inflammation and oxidant-stress in  -thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial","year":2008,"lang":"en","type":"article","venue":"Haematologica","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Center for Research Resources; Translational Cancer Research Network; Children's Hospital of Philadelphia; University College London; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; New England Research Institutes","keywords":"Deferasirox; Malondialdehyde; Deferoxamine; Ferritin; Oxidative stress; Transferrin saturation; Medicine; Internal medicine; Transferrin; Deferiprone; Thalassemia; Gastroenterology; Serum ferritin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282374,0.0002394009,0.0005629359,0.0001230152,0.0001457413,0.00000900496,0.0001099989,0.000246575,0.00002575836],"category_scores_gemma":[0.0001756059,0.0001199363,0.00004545883,0.0005241224,0.0001817733,0.0001071441,0.00005725394,0.0002678292,0.000002327452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004287075,"about_ca_system_score_gemma":0.00007302927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001893245,"about_ca_topic_score_gemma":0.0003869566,"domain_scores_codex":[0.9982885,0.0001807947,0.0005452362,0.0003454142,0.0003675676,0.0002724916],"domain_scores_gemma":[0.9991013,0.00007152255,0.0002359434,0.0003743633,0.000108701,0.0001081627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01147709,0.001888344,0.9825688,0.00008497111,0.00004646545,0.0003286033,0.002332008,0.00002636844,0.0004772865,0.000008906924,0.00001796475,0.0007431773],"study_design_scores_gemma":[0.0477367,0.006123784,0.9396802,0.0001824027,0.000137642,0.0003814435,0.002127765,0.0001048953,0.003306108,0.000003664542,0.00002093016,0.0001944752],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975262,0.00009386565,0.000001130591,0.00006526172,0.00004960557,0.001968604,0.000006866565,0.00005085381,0.0002376658],"genre_scores_gemma":[0.9996257,0.0001110479,0.0000544916,0.00002592061,0.0000161622,0.00005854966,0.00002203042,0.00002076194,0.00006534324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04288862,"threshold_uncertainty_score":0.4890859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02041424965185995,"score_gpt":0.2410175303668625,"score_spread":0.2206032807150025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}