{"id":"W2125610771","doi":"10.3324/haematol.11755","title":"Inflammation and oxidant-stress in  -thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial","year":2008,"lang":"en","type":"article","venue":"Haematologica","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Center for Research Resources; Translational Cancer Research Network; Children's Hospital of Philadelphia; University College London; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; New England Research Institutes","keywords":"Deferasirox; Malondialdehyde; Deferoxamine; Ferritin; Oxidative stress; Transferrin saturation; Medicine; Internal medicine; Transferrin; Deferiprone; Thalassemia; Gastroenterology; Serum ferritin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002548745,0.0006831529,0.001453824,0.0001831908,0.000300533,0.0006541948,0.0004224616,0.0007583285,0.001350807],"category_scores_gemma":[0.001455777,0.0003221443,0.0009653226,0.000221635,0.0004875356,0.0003380365,0.0003011049,0.00117996,0.0002096295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004823329,"about_ca_system_score_gemma":0.0007586979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009104073,"about_ca_topic_score_gemma":0.00157184,"domain_scores_codex":[0.999049,0.0006321322,0.00004647799,0.00008720093,0.00007643029,0.0001087645],"domain_scores_gemma":[0.9985475,0.0003463191,0.0004189652,0.0001035048,0.00008943385,0.0004942057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8741469,0.007325813,0.07044245,0.0006932492,0.002357483,0.0002168516,0.000197743,0.0003560475,0.008082081,0.00009503408,0.0009599369,0.0351264],"study_design_scores_gemma":[0.4405872,0.3133976,0.2373405,0.0002046816,0.003188245,0.0005380473,0.0001393206,0.0009029318,0.001652902,0.0001459744,0.001848669,0.0000539443],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970586,0.00229537,0.00004909657,0.0001243322,0.00002403121,0.0001214899,0.00009654812,0.000004464395,0.0002260403],"genre_scores_gemma":[0.9981248,0.0006814305,0.0001772541,0.0002289727,0.00009945784,0.0001428867,0.0003386057,0.000001762446,0.0002048671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002548745,"threshold_uncertainty_score":0.01347917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02041424965185995,"score_gpt":0.2410175303668625,"score_spread":0.2206032807150025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}