{"id":"W2125636874","doi":"10.1002/jps.24195","title":"Effects of 1α,25-Dihydroxyvitamin D 3 , the Natural Vitamin D Receptor Ligand, on the Pharmacokinetics of Cefdinir and Cefadroxil, Organic Anion Transporter Substrates, in Rat","year":2014,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Research Foundation of Korea","keywords":"Cefdinir; Probenecid; Cefadroxil; Chemistry; Organic anion transporter 1; Pharmacokinetics; Pharmacology; Bioavailability; Kidney; Transporter; Oral administration; Calcitriol receptor; Internal medicine; Endocrinology; Receptor; Cephalosporin; Biochemistry; Medicine; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005129984,0.0007437599,0.0007522585,0.0006892863,0.0003924613,0.0007419349,0.0004717483,0.001026557,0.001967832],"category_scores_gemma":[0.001160527,0.0007875136,0.000845467,0.000421907,0.001176931,0.00111879,0.0001641828,0.001700337,0.0007594166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001074587,"about_ca_system_score_gemma":0.001345482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007333708,"about_ca_topic_score_gemma":0.01084118,"domain_scores_codex":[0.9995611,0.0001118663,0.00002839269,0.0001079487,0.00005260453,0.0001380809],"domain_scores_gemma":[0.9985563,0.0005159442,0.0002509984,0.0002022424,0.0001053716,0.0003691303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1299697,0.002686655,0.00284393,0.0002267906,0.0002465332,0.0005265437,0.0004965905,0.00214532,0.8330243,0.0007468049,0.001485163,0.0256016],"study_design_scores_gemma":[0.001623754,0.02792153,0.01335099,0.00002291323,0.0005598179,0.0004869523,0.0003793584,0.004239842,0.9459479,0.0003868238,0.004923425,0.0001567582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927993,0.002655607,0.0009883345,0.0002975239,0.0001239744,0.00003242765,0.001412625,0.0002324742,0.001457614],"genre_scores_gemma":[0.9847303,0.002681073,0.001501383,0.0002085556,0.00007636856,0.00006198969,0.001356655,0.0001080088,0.009275613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007333708,"threshold_uncertainty_score":0.01458204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02185404471117293,"score_gpt":0.3167521216749378,"score_spread":0.2948980769637649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}