{"id":"W2125639616","doi":"10.1038/nchembio.275","title":"Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis","year":2009,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":250,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; U.S. Public Health Service","keywords":"Cystic fibrosis; Histone deacetylase; Cystic fibrosis transmembrane conductance regulator; HDAC6; Gene silencing; Chloride channel; Cell biology; Loss function; HDAC4; Cancer research; Biology; Chemistry; Histone; Biochemistry; Phenotype; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003362371,0.0003515943,0.0007010992,0.0005319062,0.000269015,0.0005334037,0.0006854385,0.0007201105,0.001954816],"category_scores_gemma":[0.0004725413,0.0003001993,0.0004943853,0.000219119,0.0007294015,0.0003024046,0.000386432,0.001300582,0.0005424119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005462453,"about_ca_system_score_gemma":0.0005124212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002002062,"about_ca_topic_score_gemma":0.001828657,"domain_scores_codex":[0.9996656,0.00004827276,0.00005527409,0.00004664971,0.00009856831,0.00008566507],"domain_scores_gemma":[0.9996257,0.00007210051,0.00006395517,0.00004365296,0.00004175914,0.0001528736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004889988,0.000109551,0.0002249357,0.00004009409,0.00002590724,0.0001452338,0.00002051966,0.0001827398,0.9959373,0.0002328631,0.0002143032,0.00237757],"study_design_scores_gemma":[0.0001575756,0.0008380766,0.004416646,0.00001379433,0.00006138696,0.0007396275,0.0001019805,0.002187947,0.9883201,0.0002649961,0.002879218,0.00001870546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942298,0.001431384,0.001933404,0.0006368724,0.0002946592,0.00002130715,0.0003890796,0.0002358499,0.0008276978],"genre_scores_gemma":[0.996733,0.0005708785,0.0005991814,0.0001285242,0.00003118606,0.00001418609,0.0002849146,0.00005384369,0.00158435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002002062,"threshold_uncertainty_score":0.006539524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082708004589348,"score_gpt":0.343917283045436,"score_spread":0.3330902029995425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}