{"id":"W2125639616","doi":"10.1038/nchembio.275","title":"Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis","year":2009,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":250,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; U.S. Public Health Service","keywords":"Cystic fibrosis; Histone deacetylase; Cystic fibrosis transmembrane conductance regulator; HDAC6; Gene silencing; Chloride channel; Cell biology; Loss function; HDAC4; Cancer research; Biology; Chemistry; Histone; Biochemistry; Phenotype; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001920375,0.0002083289,0.0004475994,0.0002279803,0.00003401157,0.000007941376,0.0001540258,0.0006664944,0.000101708],"category_scores_gemma":[0.003619971,0.0001739,0.00009146115,0.0005419548,0.0001219863,0.00005580877,0.00005533756,0.001090013,0.00004746273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004740538,"about_ca_system_score_gemma":0.0001011063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003246152,"about_ca_topic_score_gemma":0.00001730928,"domain_scores_codex":[0.9983552,0.00008373303,0.0002415312,0.0005826369,0.0002223444,0.0005145383],"domain_scores_gemma":[0.9988147,0.0003362644,0.00005451137,0.0003682246,0.0001085991,0.0003177017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004690267,0.0002192312,0.0005871291,0.00003386879,0.00001283024,0.00002027048,0.00002226876,0.000001302091,0.9515232,0.0001236626,0.004856576,0.03790935],"study_design_scores_gemma":[0.001597386,0.001325276,0.05817166,0.0001215104,0.00002920463,0.00003767433,0.000007716846,0.00002612912,0.9159124,0.001113603,0.02144791,0.0002094737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901328,0.002252455,0.0001047087,0.006297684,0.0002021969,0.0004485777,0.00001944012,0.00009093621,0.0004511722],"genre_scores_gemma":[0.9935593,0.00003442023,0.004716914,0.001085052,0.000266765,0.00004971289,0.00009479041,0.00001434608,0.0001786854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05758453,"threshold_uncertainty_score":0.7091435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082708004589348,"score_gpt":0.343917283045436,"score_spread":0.3330902029995425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}