{"id":"W2125645136","doi":"10.1152/physiolgenomics.00154.2007","title":"Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca<sup>2+</sup>binding and myofilament contractility","year":2008,"lang":"en","type":"article","venue":"Physiological Genomics","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Child and Family Research Institute; Simon Fraser University","funders":"National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of British Columbia and Yukon; American Heart Association","keywords":"Myofilament; Contractility; Troponin C; Biology; Sarcomere; Hypertrophic cardiomyopathy; Troponin; Troponin I; Myocyte; Binding site; Internal medicine; Cardiomyopathy; Endocrinology; Molecular biology; Biophysics; Biochemistry; Heart failure; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670719,0.0004214558,0.0002682201,0.0001469515,0.0001840264,0.000134489,0.0002127473,0.0005571601,0.001132038],"category_scores_gemma":[0.0003017408,0.0001280999,0.0002677157,0.0001031247,0.0004028912,0.00009601723,0.000248514,0.0003558188,0.0004911984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002348269,"about_ca_system_score_gemma":0.0001273761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001428955,"about_ca_topic_score_gemma":0.0014156,"domain_scores_codex":[0.9998301,0.00003573465,0.00002168276,0.00004819145,0.00004014898,0.00002403644],"domain_scores_gemma":[0.9998268,0.000047294,0.00003841566,0.00001372834,0.00001597382,0.0000577817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001648494,0.00004032446,0.002495219,0.00001732606,0.00001039205,0.002766238,0.00003272947,0.000111393,0.9932061,0.00004584903,0.00008848443,0.00102118],"study_design_scores_gemma":[0.0002344858,0.001113174,0.1408435,0.00002255926,0.00007187479,0.04639447,0.0001741278,0.007892358,0.798189,0.0002695388,0.00474204,0.00005286841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984434,0.0001835895,0.0008056602,0.00005317362,0.00001223511,0.00001562628,0.0001332828,0.00001884123,0.0003340807],"genre_scores_gemma":[0.9984701,0.0001097368,0.0006320724,0.00005098786,0.000007675941,0.00001118773,0.0001678268,0.00001129122,0.0005391737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001428955,"threshold_uncertainty_score":0.003787041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02529919402934539,"score_gpt":0.2464177777444501,"score_spread":0.2211185837151047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}