{"id":"W2125645136","doi":"10.1152/physiolgenomics.00154.2007","title":"Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca<sup>2+</sup>binding and myofilament contractility","year":2008,"lang":"en","type":"article","venue":"Physiological Genomics","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Child and Family Research Institute; Simon Fraser University","funders":"National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of British Columbia and Yukon; American Heart Association","keywords":"Myofilament; Contractility; Troponin C; Biology; Sarcomere; Hypertrophic cardiomyopathy; Troponin; Troponin I; Myocyte; Binding site; Internal medicine; Cardiomyopathy; Endocrinology; Molecular biology; Biophysics; Biochemistry; Heart failure; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003135157,0.0003738602,0.001124809,0.00006664059,0.000421711,0.00001910655,0.00008031054,0.0002456545,0.00001878365],"category_scores_gemma":[0.0002351322,0.00029722,0.0004218246,0.0001825202,0.0004386116,0.00008666491,0.0001521852,0.0004371388,0.00005857558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002898722,"about_ca_system_score_gemma":0.00008767593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006194057,"about_ca_topic_score_gemma":3.484334e-7,"domain_scores_codex":[0.9979117,0.0002443392,0.0003855159,0.0006695302,0.0002772146,0.0005117246],"domain_scores_gemma":[0.9989867,0.0002159311,0.0001194766,0.00034089,0.0001032182,0.0002337753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00375079,0.0008592868,0.03025932,0.0003408455,0.002372934,0.002243232,0.007600333,0.006379175,0.9305051,0.0003881374,0.003359189,0.01194168],"study_design_scores_gemma":[0.006827107,0.002421648,0.9624873,0.000106326,0.001261904,0.001279763,0.003312985,0.006227884,0.008823204,0.0004939525,0.005564038,0.001193877],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949464,0.002669868,0.00003887968,0.0001690518,0.0003242927,0.0008545099,0.00008900823,0.0001342087,0.0007737765],"genre_scores_gemma":[0.9956758,0.002964221,0.0002817894,0.0002156614,0.00050287,0.00007321493,0.0001356659,0.00002949687,0.0001212635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.932228,"threshold_uncertainty_score":0.999948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02529919402934539,"score_gpt":0.2464177777444501,"score_spread":0.2211185837151047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}