{"id":"W2125658800","doi":"10.2174/1381612811319180004","title":"Targeting the Ubiquitin E1 as a Novel Anti-Cancer Strategy","year":2013,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Proteasome; Ubiquitin; Protein degradation; Bortezomib; Cancer research; Biology; Proteasome inhibitor; Cell biology; Chemistry; Multiple myeloma; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007767114,0.0007326893,0.0009138352,0.00006117082,0.0002248705,0.0001753314,0.0009144082,0.0004533169,0.0008435865],"category_scores_gemma":[0.0001881592,0.0004772634,0.0005388891,0.0002137812,0.0002362766,0.000008283862,0.0003583726,0.001024669,0.0006121548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004480294,"about_ca_system_score_gemma":0.0006421562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003452737,"about_ca_topic_score_gemma":9.126811e-8,"domain_scores_codex":[0.9966307,0.0006518252,0.0007128257,0.000866901,0.0003305555,0.0008072163],"domain_scores_gemma":[0.9985476,0.0001550772,0.0003338454,0.0005067109,0.0001366493,0.0003201693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001512324,0.0001700327,6.235759e-7,0.004098684,0.0002155781,0.000002614797,0.000009850655,0.00001703188,0.01310956,0.0002861746,0.01426646,0.9678082],"study_design_scores_gemma":[0.0003274548,0.0001151382,1.352279e-7,0.001479712,0.0004719183,0.00002876837,0.000007294353,0.000200915,0.0181346,0.00003295914,0.9785764,0.0006247489],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002594155,0.9891035,0.006733739,0.00004953625,0.0008063071,0.002485001,0.0001731767,0.00004407304,0.0005787389],"genre_scores_gemma":[0.0001425201,0.9951587,0.0002377191,0.000204141,0.001804191,0.001359298,0.0003737538,0.0001138225,0.0006058898],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9671835,"threshold_uncertainty_score":0.9997679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2379727182003208,"score_gpt":0.4398221926127668,"score_spread":0.2018494744124461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}