{"id":"W2125669948","doi":"10.1038/nsmb.2093","title":"Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain","year":2011,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Chromatin; Homeotic gene; Histone H3; PHD finger; Histone; Genetics; Histone methylation; Chromodomain; HMG-box; Histone methyltransferase; Molecular biology; DNA-binding protein; Transcription factor; DNA; Gene; Gene expression; DNA methylation; RNA; Zinc finger","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134326,0.0003516721,0.0003405779,0.0000915656,0.0001520626,0.00001484113,0.0006004969,0.001138851,0.00004905858],"category_scores_gemma":[0.0001521366,0.0002426449,0.0002819648,0.0002816118,0.0002737667,0.000006315507,0.0002946797,0.0005459705,8.550362e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002522605,"about_ca_system_score_gemma":0.00006329726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002497305,"about_ca_topic_score_gemma":0.00005339764,"domain_scores_codex":[0.9979014,0.0004028124,0.0004393626,0.0006057011,0.0002011756,0.0004494886],"domain_scores_gemma":[0.9986801,0.000009923874,0.0003535028,0.0007003314,0.0001594067,0.00009672878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001300264,0.00001160564,0.002895347,0.00002852228,0.00008928075,0.000003031461,0.00006878327,0.000002200972,0.989648,0.006389882,0.0000309569,0.0007023776],"study_design_scores_gemma":[0.0006038657,0.0004086214,0.008597677,0.00002146128,0.00003502618,0.00002157255,0.00003603421,0.000004115968,0.9575955,0.03059027,0.001784188,0.0003017057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942098,0.002239225,0.00168011,0.00009513643,0.0005614348,0.0007283455,0.0001700427,0.00001512135,0.0003007387],"genre_scores_gemma":[0.9915797,0.00001450739,0.007587302,0.0002197788,0.0001653444,0.00001515157,0.0002918885,0.00004260245,0.00008378705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03205252,"threshold_uncertainty_score":0.989477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006725187630816488,"score_gpt":0.2649112885151439,"score_spread":0.2581861008843274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}