{"id":"W2125685404","doi":"10.1186/1471-2164-13-91","title":"Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons","year":2012,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"CHDI Foundation; Agence Nationale de la Recherche; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; European Huntington's Disease Network; Hereditary Disease Foundation","keywords":"Biology; Huntingtin; RNA interference; Neuroprotection; Huntington's disease; Gene; Candidate gene; Genetics; Huntingtin Protein; Neuroscience; Genetic screen; Mutant; Disease; RNA; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001826739,0.0008371362,0.0003319868,0.0006082217,0.0002958302,0.000240288,0.0003386687,0.0003567328,0.001227208],"category_scores_gemma":[0.000139155,0.000173158,0.0003767783,0.000276789,0.0002582424,0.00008221522,0.0002051858,0.0003686137,0.000350608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004113647,"about_ca_system_score_gemma":0.0003016597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00149816,"about_ca_topic_score_gemma":0.003953317,"domain_scores_codex":[0.9998465,0.00001162213,0.00001791045,0.00004811738,0.00005719309,0.00001870801],"domain_scores_gemma":[0.9998001,0.00006126524,0.00007346929,0.00001620401,0.00001817586,0.00003070197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003729717,0.00002035089,0.0002252869,0.00003532856,0.000009421968,0.00006962091,0.000004568035,0.00009609765,0.9985261,0.00002948278,0.0000471484,0.0008993545],"study_design_scores_gemma":[0.00004095071,0.0003660525,0.01931752,0.00001903486,0.0001362867,0.0004848113,0.00002597589,0.00295349,0.973662,0.00006374891,0.002912625,0.0000175504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789903,0.0008211642,0.0120804,0.00009200559,0.00003216946,0.0002631121,0.005023125,0.0007004812,0.001997265],"genre_scores_gemma":[0.9694197,0.0009103281,0.02046139,0.0001513606,0.00001090221,0.0002860748,0.005503521,0.0001930044,0.003063689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00149816,"threshold_uncertainty_score":0.004105389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04468726715721994,"score_gpt":0.2462729922169813,"score_spread":0.2015857250597614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}