{"id":"W2125686120","doi":"10.4049/jimmunol.177.7.4322","title":"Transient Receptor Potential Vanilloid Subtype 1 Mediates Microglial Cell Death In Vivo and In Vitro via Ca2+-Mediated Mitochondrial Damage and Cytochrome <i>c</i> Release","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Korea Science and Engineering Foundation","keywords":"Capsazepine; TRPV1; Microglia; Resiniferatoxin; Cell biology; Chemistry; Transient receptor potential channel; Programmed cell death; Intracellular; Molecular biology; Pharmacology; Receptor; Apoptosis; Biology; Biochemistry; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003197223,0.0008128448,0.0007025693,0.0002750921,0.0003231095,0.0003522151,0.0002561309,0.0006275468,0.0008792878],"category_scores_gemma":[0.000201475,0.0001999189,0.0005459459,0.0002034821,0.0002994927,0.0004284959,0.000238024,0.000723234,0.000393064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004128221,"about_ca_system_score_gemma":0.0002482753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005638516,"about_ca_topic_score_gemma":0.0007253599,"domain_scores_codex":[0.999721,0.00004792387,0.00002182478,0.00004505175,0.00006622457,0.00009795284],"domain_scores_gemma":[0.9998568,0.00001609511,0.00006448261,0.00001624615,0.00002032721,0.00002599107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004573624,0.00005569665,0.0002788886,0.000192676,0.00002231852,0.0003436234,0.00003663955,0.00006069587,0.9967456,0.00006604264,0.00006132483,0.001679074],"study_design_scores_gemma":[0.00008048917,0.001741598,0.01259515,0.00002843994,0.00009857442,0.001783432,0.00009713608,0.001063336,0.9800472,0.0002573998,0.002191714,0.00001546453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724355,0.01778315,0.007110667,0.0003282807,0.0001557645,0.0001009764,0.000379058,0.0001326019,0.001574022],"genre_scores_gemma":[0.9897044,0.006010118,0.002143415,0.0001250817,0.00009545509,0.000118897,0.0003854045,0.00001229849,0.001404973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008792878,"threshold_uncertainty_score":0.002995253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0063373559962047,"score_gpt":0.2005301431909329,"score_spread":0.1941927871947282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}