{"id":"W2125686120","doi":"10.4049/jimmunol.177.7.4322","title":"Transient Receptor Potential Vanilloid Subtype 1 Mediates Microglial Cell Death In Vivo and In Vitro via Ca2+-Mediated Mitochondrial Damage and Cytochrome <i>c</i> Release","year":2006,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Korea Science and Engineering Foundation","keywords":"Capsazepine; TRPV1; Microglia; Resiniferatoxin; Cell biology; Chemistry; Transient receptor potential channel; Programmed cell death; Intracellular; Molecular biology; Pharmacology; Receptor; Apoptosis; Biology; Biochemistry; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003386098,0.0001912774,0.0003635591,0.000276906,0.0001033571,0.00002524392,0.000260915,0.0001717243,0.00005678673],"category_scores_gemma":[0.0001026802,0.0001305826,0.00005988294,0.0002199475,0.0003273929,0.0001532431,0.00006659145,0.0005626301,0.000006309747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005854902,"about_ca_system_score_gemma":0.0000719113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002913874,"about_ca_topic_score_gemma":0.00006619326,"domain_scores_codex":[0.9981672,0.0004905342,0.0005809818,0.0001997206,0.0001890251,0.000372494],"domain_scores_gemma":[0.9991681,0.0003174457,0.0003027492,0.0001005227,0.00004741367,0.0000637797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002269545,0.0001596764,0.00004984505,0.000008337958,0.000005628131,0.000109905,0.0006221865,0.0001093473,0.996416,0.000002970371,0.0001584884,0.0000881188],"study_design_scores_gemma":[0.003510505,0.0003684285,0.001157838,0.0000210898,0.00002224423,0.000492042,0.0001610032,0.0002202883,0.9932711,0.0001143444,0.0005116133,0.0001494696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964927,0.001037942,0.00005322641,0.0007434824,0.001403325,0.0001981299,0.00003069141,0.000008760861,0.00003175832],"genre_scores_gemma":[0.9975351,0.001772681,0.0001172542,0.0001552935,0.00029633,0.000002291786,0.000002415735,0.00002014392,0.00009850477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003144818,"threshold_uncertainty_score":0.5325003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0063373559962047,"score_gpt":0.2005301431909329,"score_spread":0.1941927871947282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}